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Youcui Xu1, Chang Yang1, Yi Wu1

  • 1Intelligent Nanomedicine Institute, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, P. R. China.

Nano Letters
|June 7, 2023
PubMed
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A novel near-infrared II (NIR-II) fluorescence probe, IR1080, effectively detects hidden cancer micrometastases. This albumin-hitchhiking probe enhances tumor visualization for precise image-guided surgery.

Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Oncology

Background:

  • Tumor metastasis is a major cause of cancer treatment failure.
  • Detecting occult micrometastases preoperatively and intraoperatively remains challenging.
  • Accurate detection is crucial for effective surgical resection and patient outcomes.

Purpose of the Study:

  • To develop a high-sensitivity fluorescence probe for detecting cancer micrometastases.
  • To enable precise image-guided surgery for improved tumor resection.
  • To enhance the visualization of metastatic disease during surgical procedures.

Main Methods:

  • Design of an in situ albumin-hitchhiking near-infrared window II (NIR-II) fluorescence probe, IR1080.
  • Covalent conjugation of IR1080 with plasma albumin for enhanced fluorescence.
Keywords:
albumin-binding proteinin situ albumin-hitchhikingmicrometastases-seekingsecond near-infrared window imagingsmall-molecule fluorescent probe

Related Experiment Videos

  • Targeting of secreted protein acidic and rich in cysteine (SPARC) overexpressed in micrometastases.

    • Main Results:

    • Albumin-hitchhiked IR1080 exhibits enhanced fluorescence brightness and high affinity for SPARC.
    • The probe effectively tracks and anchors micrometastases, improving detection rates.
    • High tumor-to-normal tissue ratios and clear margin delineation were achieved.

    Conclusions:

    • IR1080 is a highly efficient strategy for diagnosing and surgically resecting micrometastases.
    • This probe facilitates precise image-guided surgery for improved cancer treatment.
    • The albumin-hitchhiking approach offers a promising method for enhanced tumor detection.