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Kin Ki Jim1,2, Joelle J N Daems3, S Matthijs Boekholdt3
1Amsterdam UMC Location University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Meibergdreef 9, Amsterdam, 1105 AZ, the Netherlands.
Abstract:
Candida infective endocarditis is a rare but serious entity that often requires aggressive treatment. However, treatment can be challenging in patients infected with drug-resistant fungi and/or with substantial comorbidity. Moreover, recommendations in treatment guidelines for these patients are based on limited clinical data due to their rarity. Here we report a case of Nakaseomyces glabrata (Candida glabrata) prosthetic valve endocarditis in a patient with congenital heart disease. This case illustrates a therapeutic dilemma for Nakaseomyces glabrata prosthetic valve endocarditis and the need for novel antifungal drugs and further clinical studies.
Insights
This case study highlights the challenges of treating Nakaseomyces glabrata (Candida glabrata) prosthetic valve endocarditis, especially in patients with congenital heart disease and drug-resistant infections. It underscores the need for new antifungal treatments and further research.
Area of Science:
- Infectious Diseases
- Cardiology
- Mycology
Background:
- Candida infective endocarditis is a rare but severe condition.
- Treatment is complicated by drug-resistant fungi and patient comorbidities.
- Limited clinical data exists for guideline recommendations in these rare cases.