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Sudesh Gourav1, Immaculata Xess1, Ashit Bhushan Xess1
1Department of Microbiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
Abstract:
Lodderomyces elongisporus is a rare cause of invasive fungal infections. Most phenotypic tests that are routinely used for identification of yeasts fail to identify this organism. However, chromogenic media for yeasts, MALDI-TOF MS and DNA sequencing can be used for correct identification. We report a case of fungemia complicated by infective endocarditis and intracerebral bleeding in a pediatric patient with previous cardiac surgery.
Insights
Lodderomyces elongisporus is a rare cause of invasive fungal infections, often missed by standard yeast identification methods. Advanced techniques like MALDI-TOF MS and DNA sequencing are crucial for accurate diagnosis.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Clinical Microbiology
Background:
- Invasive fungal infections pose significant challenges in clinical settings.
- Accurate identification of fungal pathogens is critical for effective treatment.
- Lodderomyces elongisporus is an emerging cause of opportunistic fungal infections.
Observation:
- Routine phenotypic identification methods frequently misidentify or fail to identify Lodderomyces elongisporus.
- This yeast can cause severe invasive infections, including fungemia.
- A pediatric case presented with fungemia, infective endocarditis, and intracerebral bleeding.
Findings:
- Chromogenic media, MALDI-TOF MS, and DNA sequencing are effective for accurate identification of Lodderomyces elongisporus.
- The study highlights the diagnostic limitations of traditional yeast identification techniques.
- Successful identification relies on utilizing advanced microbiological methods.
Implications:
- Improved diagnostic strategies are needed to detect rare yeasts like Lodderomyces elongisporus.
- Early and accurate diagnosis can lead to timely and appropriate antifungal therapy.
- This case underscores the importance of considering rare fungal pathogens in immunocompromised or post-surgical patients.