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Felix Ellett1,2,3, Nazli I Kacamak4,5, Carla R Alvarez4,5

  • 1Department of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Boston, MA, USA.

Journal of Oral Microbiology
|June 7, 2023
PubMed
Summary
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Fusobacterium nucleatum (Fn) survives inside human neutrophils, which then transport the bacteria. This neutrophil-mediated bacterial dissemination may link oral bacteria to systemic diseases like colon cancer.

Area of Science:

  • Microbiology
  • Immunology
  • Pathogen-host interactions

Background:

  • Fusobacterium nucleatum (Fn), an oral bacterium, is increasingly linked to systemic diseases, including colon cancer and Alzheimer's.
  • The precise mechanisms driving these associations remain largely unknown.
  • Understanding how Fn spreads from the oral cavity to other parts of the body is crucial.

Purpose of the Study:

  • To investigate the interaction between Fusobacterium nucleatum and human neutrophils.
  • To elucidate the role of neutrophils in the dissemination of Fn.

Main Methods:

  • Utilized in vitro microfluidic devices to model neutrophil-bacterial interactions.
  • Observed Fn survival and transport within human neutrophils post-phagocytosis.
  • Validated findings in vivo using a zebrafish model to track neutrophil-mediated bacterial dissemination.
Keywords:
Fusobacterium nucleatumMicrofluidicNeutrophilPhagocytosisTrojan HorseZebrafish

Related Experiment Videos

Main Results:

  • Demonstrated that Fusobacterium nucleatum can survive within human neutrophils after being engulfed.
  • Showed that neutrophils protect and transport Fn over significant distances in vitro.
  • Confirmed in vivo that neutrophils disseminate Fn, supporting their role in spreading the bacteria.

Conclusions:

  • Neutrophils play a critical role in disseminating Fusobacterium nucleatum, potentially linking oral infections to systemic diseases.
  • Bacterial dissemination by neutrophils represents a key mechanism connecting oral microbiota to distant pathologies.
  • These findings open avenues for therapeutic strategies targeting host-bacterial interactions, specifically the dissemination process.