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Related Experiment Video

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Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice

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Neurooncology: 2023 update.

Michel Mittelbronn^1,2,3,4,5,6

¹National Center of Pathology (NCP), Laboratoire National de Santé (LNS), Dudelange, Luxembourg.

Free Neuropathology

|June 7, 2023

Summary

This summary is machine-generated.

Neuropathology research in 2022 advanced diagnostic tools for brain tumors, including machine learning and molecular profiling. Despite progress, patient prognosis for nervous system malignancies remains challenging, necessitating focus on sustainable application of these innovations.

Keywords:

Brain metastasis Brain tumors Glioblastoma Meningioma Neuro-oncology Neuropathology

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Area of Science:

Neuropathology
Neuro-oncology
Molecular Diagnostics

Background:

Significant advancements in neuropathology research occurred in 2022, particularly in neuro-oncology.
The development of precise, rapid, and less invasive diagnostic tools has been a key focus.

Purpose of the Study:

To highlight key neuropathological advancements in neuro-oncology from 2022.
To introduce a newly described tumor entity and innovative treatment approaches.

Main Methods:

Immunohistochemical prediction of 1p/19q loss in diffuse glioma.
Methylation analyses in cerebrospinal fluid (CSF) samples.
Molecular profiling for central nervous system (CNS) lymphoma.
Proteomic analyses of recurrent glioblastoma.
Integrated molecular diagnostics for meningioma stratification.
Intraoperative profiling using Raman spectroscopy or methylation analysis.
Machine learning for predicting molecular tumor features from histological slides.
Drug screening platform for brain metastasis.

Main Results:

Development of advanced diagnostic tools for various brain tumors, enhancing precision and speed.
Identification and description of a new tumor entity: high-grade glioma with pleomorphic and pseudopapillary features (HPAP).
Presentation of a novel drug screening platform for brain metastases.

Conclusions:

While diagnostic capabilities have rapidly improved, clinical prognosis for patients with malignant nervous system tumors has not significantly changed in the past decade.
Future neuro-oncology research must focus on the sustainable application of these diagnostic and therapeutic innovations to improve patient outcomes.