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Yiduo Xu1,2,3, Bing Wang1,2, Feifei Zhang1,2

  • 1Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, China.

Quantitative Imaging in Medicine and Surgery
|June 7, 2023
PubMed
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This summary is machine-generated.

18F-FDG PET-CT identified pulmonary FDG uptake and epicardial fat volume as key predictors of mortality in dermatomyositis patients without cancer. Patients with both factors face a worse prognosis, necessitating early intervention.

Area of Science:

  • Rheumatology
  • Nuclear Medicine
  • Cardiology
  • Oncology Screening

Background:

  • 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT) is standard for malignancy screening in dermatomyositis (DM).
  • The prognostic value of 18F-FDG PET-CT in DM patients without malignancy remains underexplored.

Purpose of the Study:

  • To evaluate the utility of 18F-FDG PET-CT in predicting prognosis for dermatomyositis patients.
  • To identify imaging biomarkers from 18F-FDG PET-CT associated with mortality risk in DM patients without cancer.

Main Methods:

  • Retrospective cohort study of 62 DM patients who underwent 18F-FDG PET-CT.
  • Analysis of clinical data, laboratory indicators, and 18F-FDG PET-CT parameters including pulmonary FDG uptake and epicardial fat volume (EFV).
Keywords:
Dermatomyositis (DM)epicardial adipose tissue (EAT)interstitial lung disease (ILD)positron emission tomography/computed tomography (PET/CT)prognostic factor

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  • Survival analysis using Cox regression and Kaplan-Meier methods with death from any cause as the endpoint.

    • Main Results:

    • 13 patients (21.0%) died during a median follow-up of 7 months.
    • High pulmonary FDG uptake and high EFV were identified as independent risk factors for mortality (P<0.004).
    • Patients with concurrent high pulmonary FDG uptake and high EFV exhibited significantly lower survival rates.

    Conclusions:

    • Pulmonary FDG uptake and EFV measured by 18F-FDG PET-CT are independent predictors of mortality in DM patients without malignancy.
    • The combined presence of high pulmonary FDG uptake and high EFV indicates a worse prognosis.
    • Early therapeutic intervention in patients with both high pulmonary FDG uptake and high EFV may improve survival outcomes.