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Sweet's syndrome with multifocal sterile osteomyelitis
American Journal of Diseases of Children (1960)
|August 1, 1986
Summary
Sweet's syndrome, a rare neutrophilic dermatosis, can manifest as sterile multifocal osteomyelitis in infants. This finding, responsive to corticosteroid therapy, expands the known clinical spectrum of this condition.
Area of Science:
- Pediatrics
- Rheumatology
- Dermatology
Background:
- Sweet's syndrome is a rare autoinflammatory disorder characterized by fever, leukocytosis, and painful cutaneous plaques.
- It typically involves dense dermal infiltration of neutrophils.
Observation:
- A 23-month-old male infant presented with typical Sweet's syndrome skin lesions and painful extremities, impairing ambulation.
- Diagnostic evaluation revealed multifocal sterile osteomyelitis in both tibiae.
Findings:
- Systemic corticosteroid therapy led to resolution of the infant's symptoms and normalization of bone scans.
- The patient experienced intermittent relapses responsive to continued corticosteroid treatment over a one-year follow-up period.
Implications:
- Sterile multifocal osteomyelitis should be considered a potential clinical manifestation of Sweet's syndrome in pediatric cases.
- This case broadens the understanding of Sweet's syndrome, highlighting its potential systemic involvement beyond the skin.