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Exploring the relationship between abnormally high expression of

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High expression of Nucleoporin 205 (NUP205) indicates poor prognosis in lower-grade glioma (LGG). NUP205 may serve as a therapeutic target for anti-LGG immunotherapy.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • The nuclear pore complex (NPC) regulates molecule exchange between the nucleus and cytoplasm.
  • Nucleoporin 205 (NUP205), a key NPC component, influences tumor cell proliferation.
  • The role of NUP205 in lower-grade glioma (LGG) progression remains largely unexplored.

Purpose of the Study:

  • To investigate the impact of NUP205 on LGG prognosis, clinicopathological features, and the tumor immune microenvironment (TIME).
  • To explore NUP205's regulatory mechanisms in LGG.
  • To assess NUP205's potential as an immunotherapy target for LGG.

Main Methods:

  • Integrated analysis of 906 LGG samples from public databases.
  • Gene Set Enrichment Analysis (GSEA) to identify regulated pathways.
  • Immune correlation analysis to assess TIME infiltration and immune checkpoints.

Main Results:

  • NUP205 expression is significantly elevated in LGG tissues compared to normal brain tissue, particularly in higher WHO grades and IDH-wild type LGG.
  • High NUP205 expression is an independent predictor of reduced survival time in LGG patients.
  • NUP205 regulates LGG progression through cell cycle, notch signaling, and aminoacyl-tRNA biosynthesis pathways.
  • Elevated NUP205 correlates with increased infiltration of M2 macrophages and higher expression of immune checkpoints like PD-L1.

Conclusions:

  • This study establishes the pathogenic role of NUP205 in LGG and expands understanding of its molecular functions.
  • NUP205 is identified as a potential prognostic biomarker and a promising therapeutic target for anti-LGG immunotherapy.