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Dehong Tan1,2,3, Wenxiang Zhu2,4, Lujie Liu2

  • 1The Research and Application Center of Precision Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China.

Theranostics
|June 7, 2023
PubMed
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This study presents a novel hydrogel wound dressing combining royal jelly-derived extracellular vesicles (RJ-EVs) and modified sericin (SerMA). The dressing effectively accelerates wound healing by reducing inflammation and enhancing blood vessel repair.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing Research

Background:

  • Inadequate wound healing is a significant clinical challenge.
  • Inflammation and impaired vascularization are key factors hindering effective healing.
  • Novel therapeutic strategies are needed to address these challenges.

Purpose of the Study:

  • To develop a versatile hydrogel wound dressing for accelerated wound healing.
  • To inhibit inflammation and promote vascular repair using royal jelly-derived extracellular vesicles (RJ-EVs) and methacrylic anhydride modified sericin (SerMA).

Main Methods:

  • Development of a hydrogel dressing via physical mixture of RJ-EVs and SerMA.
  • In vitro assessment of RJ-EVs' anti-inflammatory, antioxidant, and cell proliferation/migration effects.
Keywords:
BiomaterialsExtracellular VesiclesHydrogelRoyal JellyWound Healing

Related Experiment Videos

  • Evaluation of the SerMA hydrogel's properties as a wound dressing.
  • In vivo testing on a full-thickness skin defect model.
  • RNA sequencing to analyze molecular pathways involved in healing.

    • Main Results:

    • RJ-EVs demonstrated significant anti-inflammatory, antioxidant, and pro-proliferative effects in vitro.
    • The SerMA hydrogel exhibited suitable properties for wound dressing applications with controlled RJ-EVs release.
    • The SerMA/RJ-EVs hydrogel dressing achieved a 96.8% healing rate in vivo by promoting cell proliferation and angiogenesis.
    • RNA sequencing identified involvement in key repair pathways like Wnt signaling and epidermis development.

    Conclusions:

    • The SerMA/RJ-EVs hydrogel dressing provides a simple, safe, and effective strategy for wound healing.
    • This approach successfully modulates inflammation and vascular impairment to accelerate tissue repair.