Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

4.3K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
4.3K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

169
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
169

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis.

Journal of experimental & clinical cancer research : CR·2022
Same author

Effects of different modes of exercise on skeletal muscle mass and function and IGF-1 signaling during early aging in mice.

The Journal of experimental biology·2022
Same author

Optimal Control of False Information Clarification System under Major Emergencies Based on Differential Game Theory.

Computational intelligence and neuroscience·2022
Same author

Ionothermal Synthesis of Fully Conjugated Covalent Organic Frameworks for High-Capacity and Ultrastable Potassium-Ion Batteries.

Advanced materials (Deerfield Beach, Fla.)·2022
Same author

Circ-OMAC drives metastasis in oral squamous cell carcinoma.

Oral diseases·2022
Same author

Biodegradation of Dibutyl Phthalate by the New Strain <i>Acinetobacter baumannii</i> DP-2.

Toxics·2022

Related Experiment Video

Updated: Jul 27, 2025

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
10:47

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Published on: February 3, 2015

8.8K

Dual targeting PET tracer [

Rongxi Wang1, Vivianne Jakobsson2,3,4, Jiarou Wang1

  • 1Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.

Theranostics
|June 7, 2023
PubMed
Summary
This summary is machine-generated.

This study shows that [68Ga]Ga-FAPI-RGD PET/CT improves lung cancer detection and metastasis identification compared to [18F]FDG PET/CT. The dual-targeting tracer [68Ga]Ga-FAPI-RGD offers advantages for diagnosing lung neoplasms.

Keywords:
FAPIntegrin αvβ3Lung neoplasm[18F]FDG[68Ga]Ga-FAPI-RGD

More Related Videos

Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression
09:06

Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression

Published on: February 3, 2023

1.5K
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

483

Related Experiment Videos

Last Updated: Jul 27, 2025

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
10:47

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Published on: February 3, 2015

8.8K
Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression
09:06

Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression

Published on: February 3, 2023

1.5K
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

483

Area of Science:

  • Oncology
  • Radiology
  • Nuclear Medicine

Background:

  • Early lung cancer detection is crucial for effective treatment.
  • Positron emission tomography/computed tomography (PET/CT) is vital for lung cancer imaging.
  • Novel PET tracers are needed to enhance diagnostic accuracy.

Purpose of the Study:

  • To assess the feasibility of [68Ga]Ga-FAPI-RGD PET/CT for detecting lung neoplasms.
  • To compare [68Ga]Ga-FAPI-RGD with [18F]FDG and single-targeting tracers ([68Ga]Ga-RGD, [68Ga]Ga-FAPI).

Main Methods:

  • A pilot study involving 51 patients with suspected lung malignancies.
  • All participants underwent [68Ga]Ga-FAPI-RGD PET/CT.
  • Comparisons included [18F]FDG PET/CT, [68Ga]Ga-FAPI PET/CT, and [68Ga]Ga-RGD PET/CT.

Main Results:

  • [68Ga]Ga-FAPI-RGD PET/CT demonstrated a higher detection rate of primary lung lesions than [18F]FDG PET/CT (91.4% vs. 77.1%).
  • It showed higher tumor uptake, improved mediastinal lymph node evaluation accuracy, and identified more metastases.
  • [68Ga]Ga-FAPI-RGD also outperformed [68Ga]Ga-RGD in primary lesion uptake.

Conclusions:

  • [68Ga]Ga-FAPI-RGD PET/CT is a promising tool for lung cancer diagnosis, offering superior performance over [18F]FDG PET/CT.
  • The dual-targeting tracer shows potential for improved lung cancer staging and metastasis detection.
  • [68Ga]Ga-FAPI-RGD warrants further investigation for both diagnostic and therapeutic applications in lung cancer.