Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Functions of the Skeletal System

The Functions of the Skeletal System

The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...

Skeleton and Calcium Homeostasis

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.

What is the Skeletal System?

What is the Skeletal System?

Overview of Metabolism

Overview of Metabolism

Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...

Hormones and Bone Tissue

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...

The Bone Matrix

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Steatosis shapes prognosis-defining liver metastasis heterogeneity in CRC.

Nature·2026

Same author

Metabolic flexibility secures skeletal progenitor function upon reduced glycolysis driven by PFKFB3 loss.

Bone·2026

Same author

Donor-Specific Blood Transfusion Induces a Transfusion-Related Early Protective Effect in Murine Lung Transplantation.

Transplant international : official journal of the European Society for Organ Transplantation·2026

Same author

Teriparatide in Two Patients With Mucopolysaccharidosis Type IVB.

JIMD reports·2026

Same author

A Circadian Trough in Glucocorticoid Signaling Is Essential for Bone Health in Mice.

Aging cell·2026

Same author

Institut Georges Lopez-2M as a Novel Lung Preservation Solution Attenuates Ischemia-Reperfusion Injury in a Rat <i>Ex Vivo</i> Lung Perfusion Model.

Transplant international : official journal of the European Society for Organ Transplantation·2026

Search research articles

Related Experiment Video

Updated: Jul 27, 2025

Assessing Energy Substrate Oxidation In Vitro with 14CO2 Trapping

Assessing Energy Substrate Oxidation In Vitro with 14CO2 Trapping

Published on: March 23, 2022

Editorial: Energy metabolism within the skeleton

Bram C J van der Eerden¹, Ryan C Riddle^2,3, Steve Stegen⁴

¹Department of Internal Medicine, Erasmus MC, Erasmus University Medical Center, Rotterdam, Netherlands.

Frontiers in Physiology

|June 7, 2023

Summary

No abstract available in PubMed .

Keywords:

amino acids bone cells energy metabolism fatty acids glucose

More Related Videos

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Published on: March 1, 2022

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases

Published on: October 4, 2024

Related Experiment Videos

Last Updated: Jul 27, 2025

Assessing Energy Substrate Oxidation In Vitro with 14CO2 Trapping

Assessing Energy Substrate Oxidation In Vitro with 14CO2 Trapping

Published on: March 23, 2022

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Published on: March 1, 2022

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases

Published on: October 4, 2024