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Platelet Selectin Levels in Patients with Cerebral Venous Sinus Thrombosis: Preliminary Findings

Eswi Zenobia1, Nushrotul Lailiyya1, Sofiati Dian1

  • 1Neurology Department, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.

Journal of Blood Medicine
|June 7, 2023
PubMed

Insights

Platelet Selectin (P-selectin) levels may indicate hypercoagulable states in Cerebral Venous Sinus Thrombosis (CVST) patients. Further research is needed to confirm P-selectin as a diagnostic marker for these conditions.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Hematology

Background:

  • Cerebral Venous Sinus Thrombosis (CVST) is a rare cerebrovascular disease with significant mortality.
  • Hypercoagulable conditions and platelet aggregation are key factors in CVST.
  • Platelet Selectin (P-selectin) is recognized as a biomarker for these conditions.

Purpose of the Study:

  • To investigate and describe the levels of P-selectin in patients diagnosed with CVST.
  • To explore the potential role of P-selectin as a diagnostic marker in CVST.

Main Methods:

  • A descriptive observational study was conducted.
  • Participants included patients aged 18 years and older diagnosed with CVST.
  • Data were collected from patients at RSUP Dr. Hasan Sadikin Bandung between March and May 2022.

Main Results:

  • Fifty-five patients with a median age of 48 were studied, predominantly women (80%).
  • Elevated P-selectin levels were observed in patients with subacute onset, infectious etiology, shorter treatment duration, history of hyper aggregation, hypercoagulation, elevated D-dimer, normal fibrinogen, and multiple sinus involvements.
  • Headaches were the most common symptom (92.7%).

Conclusions:

  • P-selectin shows potential as a diagnostic marker for hyper aggregation and hypercoagulable states in CVST patients.
  • Additional research is required to validate P-selectin's diagnostic utility in CVST.
Abstract

Keywords:
Cerebral Venous Sinus ThrombosisP-selectinhypercoagulationplatelet hyperaggregation

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