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Updated: Jul 27, 2025
A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death
Published on: June 6, 2025
Transplantation Outcomes with Donor Hearts after Circulatory Death
Jacob N Schroder1, Chetan B Patel1, Adam D DeVore1
1From Duke University Medical Center, Durham, NC (J.N.S., C.B.P., A.D.D., S.C., C.A.M.); Northwestern University (B.S.B., D.T.P.) and the University of Chicago (C.T.S.) - both in Chicago; Vanderbilt University Medical Center, Nashville (A.S., T.A.); University of Wisconsin Hospital and Clinics, Madison (J.W.S.), and the Medical College of Wisconsin, Milwaukee (D.L.J.); the University of California, San Francisco, San Francisco (A.G.F.), the University of California, San Diego, La Jolla (V.P.), Cedars-Sinai Medical Center, Los Angeles (F.E.), and Stanford University Medical Center, Stanford (Y.S.) - all in California; Emory University Hospital, Atlanta (M.D., T.S.A.); Advent Health, Orlando (S.S.), Mayo Clinic, Jacksonville (S.M.P.), and Tampa General Hospital, Tampa (J.D., L.L.) - all in Florida; Yale School of Medicine, New Haven, CT (A.G.); Nebraska Medical Center, Omaha (J.Y.U.); Columbia University Medical Center, New York (K.T.), Montefiore Medical Center, Bronx (D.J.G.), and Westchester Medical Center, Valhalla (M.K.) - all in New York; Minneapolis Heart Institute Foundation (K.M., B.S., B.C.S.) and the University of Minnesota Medical Center (A.W.S.) - both in Minneapolis; Sentara Norfolk General Hospital, Norfolk (J.P.), and Virginia Commonwealth University, Richmond (M.A.Q.) - both in Virginia; Tufts Medical Center (G.S.C.), Brigham and Women's Hospital (H.R.M., M.M.G., M.R.M.), and Massachusetts General Hospital (J.C.M., D.A.D.) - all in Boston; and the University of Texas Southwestern Medical Center, Dallas (M.F.).
Hearts from donors after circulatory death (DCD) show comparable 6-month survival to those from donors after brain death (DBD) in heart transplantation. This study demonstrates DCD hearts are a safe and effective alternative, expanding donor options for patients awaiting transplants.
Area of Science:
- Cardiovascular Surgery
- Transplantation Medicine
- Donor Organ Utilization
Background:
- Limited data exists on the efficacy and safety of heart transplantation using donors after circulatory death (DCD) compared to donors after brain death (DBD).
- Expanding donor heart sources is critical for addressing organ shortages in heart transplantation.
Purpose of the Study:
- To compare the efficacy and safety of heart transplantation using DCD donors versus DBD donors.
- To assess 6-month survival rates and serious adverse events in recipients of DCD versus DBD hearts.
Main Methods:
- A randomized, noninferiority trial comparing heart transplantation from DCD donors (using extracorporeal perfusion) versus standard DBD donors (using cold storage).
- Adult heart transplant candidates were assigned in a 3:1 ratio to DCD or DBD groups.
- Primary endpoint: risk-adjusted 6-month survival; Secondary endpoint: serious adverse events at 30 days post-transplant.
Main Results:
- Risk-adjusted 6-month survival was 94% in the DCD group versus 90% in the DBD group, demonstrating noninferiority (P<0.001).
- No significant differences in serious adverse events related to the heart graft were observed between the DCD and DBD groups at 30 days.
- The study included 166 transplant recipients in the primary analysis (80 DCD, 86 DBD).
Conclusions:
- Heart transplantation using DCD donor hearts reanimated and assessed with extracorporeal perfusion is noninferior to standard DBD heart transplantation.
- This approach expands the donor pool and offers a safe and effective alternative for heart transplant recipients.
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