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Effectiveness of biosurfactant lipopeptide adhesive mucus paste on the healing process of oral wounds: a randomized
Yasamin Shahsavani1, Mandana Ohadi2, Gholamreza Dehghannoudeh2
1Department of Oral Medicine, Dental School, Kerman University of Medical Sciences, Kerman, Iran.
Introduction:
Recurrent aphthous stomatitis is a common lesion of the oral cavity, and many treatments have been introduced by researchers.
Objective:
This study aims to determine the effect of biosurfactant lipopeptide (Acinetobacter baumannii and Pseudomonas aeruginosa) adhesive mucus paste on the healing process of oral wounds.
Materials And Methods:
The studied population included 36 people (age range, 20-41 years). The volunteers had a history of oral ulcers and were randomly assigned to 3 groups: positive control (mouthwash chlorhexidine 0.2%), biosurfactant lipopeptide mucoadhesive (A baumannii and P aeruginosa), and base groups. In this analysis, the 2-paired sample t test, ANOVA, and Kruskal-Wallis test (Wilcoxon signed-rank test) were used.
Results:
On the second day of treatment, the efficacy index of the positive control group was higher than that of the mucoadhesive and the base groups (P = .04) and there was a significant difference between the mucoadhesive group and the positive control group compared with the base group (P = .001). On the sixth day of treatment, the positive control group was significantly different from the mucoadhesive and base groups in terms of wound size (P < .05).
Conclusions:
This study showed that the use of mucoadhesive gel formation containing lipopeptide biosurfactant reduces pain and wound size compared to mucoadhesive without biosurfactant lipopeptide treatment, but it has less effect than routine treatment. Therefore, other studies should be done.
