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Published on: December 5, 2015
Hybrid nanoarchitectonics of molybdenum dioxide (MoO
Hong-Ying Xia1, Bo-Yi Li1, Ranjith Kumar Kankala2
1Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, PR China.
Abstract:
Cancer has emerged as one of the severe ailments due to the uncontrolled proliferation rate of cells, accounting for millions of deaths annually. Despite the availability of various treatment strategies, including surgical interventions, radiation, and chemotherapy, tremendous advancements in the past two decades of research have evidenced the generation of different nanotherapeutic designs toward providing synergistic therapy. In this study, we demonstrate the assembly of a versatile nanoplatform based on the hyaluronic acid (HA)-coated molybdenum dioxide (MoO2) assemblies to act against breast carcinoma. The hydrothermal approach-assisted MoO2 constructs are immobilized with doxorubicin (DOX) molecules on the surface. Further, these MoO2-DOX hybrids are encapsulated with the HA polymeric framework. Furthermore, the versatile nanocomposites of HA-coated MoO2-DOX hybrids are systematically characterized using various characterization techniques, and explored biocompatibility in the mouse fibroblasts (L929 cell line), as well as synergistic photothermal (808-nm laser irradiation for 10 min, 1 W/cm2) and chemotherapeutic properties against breast carcinoma (4T1 cells). Finally, the mechanistic views concerning the apoptosis rate are explored using the JC-1 assay to measure the intracellular mitochondrial membrane potential (MMP) levels. In conclusion, these findings indicated excellent photothermal and chemotherapeutic efficacies, exploring the enormous potential of MoO2 composites against breast cancer.
Insights
This study presents a novel hyaluronic acid-coated molybdenum dioxide-doxorubicin nanoplatform for synergistic cancer therapy. The nanoconstructs show significant promise for treating breast carcinoma through combined chemotherapy and photothermal effects.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Cancer, particularly breast carcinoma, remains a leading cause of mortality worldwide.
- Current treatments like chemotherapy and radiation have limitations, driving research into advanced nanotherapeutics.
- Hyaluronic acid (HA)-coated molybdenum dioxide (MoO2) nanoplatforms offer potential for synergistic cancer therapy.
Purpose of the Study:
- To develop and characterize a versatile nanoplatform based on HA-coated MoO2 assemblies for breast cancer treatment.
- To investigate the synergistic chemotherapeutic and photothermal properties of the nanoplatform.
- To evaluate the biocompatibility and apoptotic effects of the nanoconstructs.
Main Methods:
- Hydrothermal synthesis of MoO2 constructs, followed by doxorubicin (DOX) immobilization and HA encapsulation.
- Characterization of the HA-coated MoO2-DOX nanocomposites.
- In vitro evaluation of biocompatibility using mouse fibroblasts (L929) and efficacy against breast carcinoma cells (4T1).
- Assessment of synergistic photothermal therapy (808-nm laser) and chemotherapy.
- Mechanistic study of apoptosis induction via JC-1 assay to measure mitochondrial membrane potential (MMP).
Main Results:
- Successful assembly of HA-coated MoO2-DOX nanocomposites with demonstrated biocompatibility.
- Significant synergistic photothermal and chemotherapeutic efficacy against 4T1 breast cancer cells.
- Evidence of apoptosis induction, indicated by changes in intracellular mitochondrial membrane potential.
Conclusions:
- The developed HA-coated MoO2-DOX nanoplatform exhibits excellent photothermal and chemotherapeutic properties.
- This nanoconstruct demonstrates significant potential as an effective therapeutic agent against breast cancer.
- Further research into MoO2-based composites for cancer therapy is warranted.
