Osteoporosis medication adherence tools: a systematic review.
Elahe Hesari1,2, Mahnaz Sanjari3, Mohammad Javad Mansourzadeh1,4
1Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Summary
Accurate measurement of osteoporosis medication adherence is crucial for treatment effectiveness. This review identifies and assesses tools, finding questionnaires most popular despite direct and electronic methods being more accurate but costly.
Area of Science:
- Pharmacology and Pharmaceutics
- Public Health and Epidemiology
- Health Services Research
Background:
- Poor adherence to osteoporosis pharmacotherapy significantly reduces treatment efficacy, leading to decreased bone mineral density and increased fracture risk.
- Reliable and practical tools are essential for accurately measuring medication adherence in osteoporosis patients.
- This systematic review aims to identify and evaluate existing tools for measuring adherence to osteoporosis medications.
Approach:
- A comprehensive literature search was conducted across PubMed, Embase, Web of Science, and Scopus databases for osteoporosis adherence measurement tools and related keywords.
- Articles were screened for relevance, with a focus on methods measuring compliance and persistence in osteoporosis pharmacotherapy.
- Data were extracted and categorized into direct methods, formulas, questionnaires, and electronic methods, with quality assessment using the Newcastle-Ottawa Quality Assessment Scale.
Key Points:
- 178 articles met inclusion criteria, identifying five main categories of adherence measurement methods: direct methods, pharmacy records, questionnaires, electronic methods, and tablet counting.
- Medication Possession Ratio (MPR) derived from pharmacy records and the Morisky Medication Adherence Scale (MMAS) via questionnaires were the most frequently utilized tools.
- Direct and electronic methods offer the highest accuracy but are often impractical due to cost.
Conclusions:
- Questionnaires represent the most widely adopted adherence measurement tools in osteoporosis research and clinical practice.
- While accurate, direct and electronic adherence measurement tools face barriers to widespread implementation due to cost.
- Further research may explore cost-effective and accurate adherence monitoring strategies for osteoporosis management.
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