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Hepatic portal glucose infusions decrease food intake and increase food preference.

M G Tordoff, M I Friedman

The American Journal of Physiology

|July 1, 1986

Summary

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Liver glucose infusions reduced food intake in rats, suggesting a hepatic mechanism for appetite control. Portal glucose also promoted learned food preferences, highlighting the liver's role in feeding behavior.

Area of Science:

Physiology
Neuroscience
Behavioral Science

Background:

The liver plays a crucial role in regulating energy balance and food intake.
Understanding the specific mechanisms by which the liver influences feeding behavior is essential for addressing metabolic disorders.

Purpose of the Study:

To investigate the role of hepatic portal glucose infusion in controlling food intake.
To determine if glucose infusion into the liver can act as an unconditioned stimulus for learned food preferences.

Main Methods:

Rats received infusions of glucose or saline via hepatic portal or jugular catheters.
Food intake was monitored during infusions paired with distinct flavors.
Subsequent flavor preferences were assessed.

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Main Results:

Hepatic portal glucose infusion significantly decreased food intake compared to saline and jugular glucose infusions.
Rats with hepatic portal catheters developed a preference for the flavor associated with glucose infusion.
Jugular glucose infusion did not affect food intake or induce flavor preference.

Conclusions:

A liver-based mechanism can reduce food intake without causing malaise.
Portal glucose acts as an unconditioned stimulus, facilitating learned food preferences.
Previous studies may have underestimated hepatic portal infusion effects due to inadequate control for prior experience.