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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
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Heart Failure Medical Therapy: A Review for Structural/Interventional Cardiologists

Alexandra Pipilas1, Trejeeve Martyn2, JoAnn Lindenfeld3

  • 1Department of Cardiovascular Medicine, Boston University, Boston, Massachusetts, USA.

Structural Heart : the Journal of the Heart Team
|June 8, 2023
PubMed

Insights

Heart failure (HF) treatments have advanced, improving patient outcomes. This review details medical therapies for heart failure across different left ventricular ejection fraction levels.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Medical therapy for heart failure (HF) has significantly evolved, improving patient morbidity and mortality.
  • Traditional HF treatment stratification is based on left ventricular ejection fraction (LVEF).
  • Optimized HF medical therapy is crucial for interventional cardiology procedures and device-based therapies.

Purpose of the Study:

  • To review current medical therapies for heart failure.
  • To highlight indicated treatments across various left ventricular ejection fraction strata.

Main Methods:

  • Literature review of recent advancements in heart failure pharmacotherapy.
  • Analysis of treatment guidelines stratified by LVEF.

Main Results:

  • Recent decade has seen rapid expansion in HF medical therapies.
  • Therapies are increasingly tailored to LVEF.
  • Optimized medical therapy is vital before interventions and clinical trial enrollment.

Conclusions:

  • Medical therapy for heart failure has expanded, improving outcomes.
  • Understanding LVEF-based treatment is essential for cardiologists.
  • This review provides a guide to HF medical therapy across LVEF spectrums.

Keywords:
CardiologyHeart failureMedical therapy

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