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Updated: Jul 27, 2025
Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches
Published on: June 16, 2023
Widespread transcriptomic alterations of transient receptor potential channel genes in cancer
Tao Pan1, Yueying Gao1, Gang Xu1
1Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, Hainan Provincial Clinical Research Center for Thalassemia, Key Laboratory of Reproductive Health Diseases Research and Translation (Hainan Medical University), Ministry of Education, Department of Reproductive Medicine, the First Affliated Hospital of Hainan Medical University, College of Biomedical Information and Engineering, Hainan Medical University, Haikou, Hainan 571199, China.
Abstract:
Ion channels, in particular transient-receptor potential (TRP) channels, are essential genes that play important roles in many physiological processes. Emerging evidence has demonstrated that TRP genes are involved in a number of diseases, including various cancer types. However, we still lack knowledge about the expression alterations landscape of TRP genes across cancer types. In this review, we comprehensively reviewed and summarised the transcriptomes from more than 10 000 samples in 33 cancer types. We found that TRP genes were widespreadly transcriptomic dysregulated in cancer, which was associated with clinical survival of cancer patients. Perturbations of TRP genes were associated with a number of cancer pathways across cancer types. Moreover, we reviewed the functions of TRP family gene alterations in a number of diseases reported in recent studies. Taken together, our study comprehensively reviewed TRP genes with extensive transcriptomic alterations and their functions will directly contribute to cancer therapy and precision medicine.
Insights
Transient Receptor Potential (TRP) channels are vital genes implicated in cancer. This study reveals widespread TRP gene dysregulation across 33 cancer types, impacting patient survival and offering new therapeutic targets.
Area of Science:
- Molecular Biology
- Oncology
- Genetics
Background:
- Ion channels, particularly Transient Receptor Potential (TRP) channels, are crucial for physiological functions.
- Growing evidence links TRP genes to various diseases, including diverse cancer types.
- A comprehensive understanding of TRP gene expression alterations across the cancer landscape is lacking.
Purpose of the Study:
- To comprehensively review and summarize the transcriptomic landscape of TRP genes across a wide range of cancer types.
- To investigate the association between TRP gene dysregulation and clinical outcomes in cancer patients.
- To explore the functional implications of TRP gene alterations in cancer and other diseases.
Main Methods:
- Analysis of transcriptomic data from over 10,000 samples across 33 distinct cancer types.
- Systematic review of recent studies on the functions of TRP family gene alterations.
- Correlation analysis between TRP gene expression patterns and patient survival data.
Main Results:
- Widespread transcriptomic dysregulation of TRP genes was observed across numerous cancer types.
- Altered TRP gene expression significantly correlated with clinical survival in cancer patients.
- Perturbations in TRP genes were associated with key cancer-related pathways.
Conclusions:
- TRP genes exhibit extensive transcriptomic alterations in cancer, influencing patient prognosis.
- Understanding these alterations provides insights into cancer pathogenesis.
- This comprehensive review highlights the potential of TRP genes as therapeutic targets for cancer therapy and precision medicine.
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