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Related Concept Videos

Nonlinear Pharmacokinetics: Role of Transporters01:27

Nonlinear Pharmacokinetics: Role of Transporters

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A drug's nonlinear kinetics can be influenced by a diverse range of transporter proteins that serve as crucial players in drug distribution. These transporters, found within cells, can enhance or reduce local drug concentrations by facilitating the influx or efflux of drugs. For instance, the expression of xenobiotic transporters can be influenced by factors such as age and gender, potentially impacting the linearity of drug response.
Polymorphisms occurring in drug transporters can alter...
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Nonlinear Pharmacokinetics: Overview01:19

Nonlinear Pharmacokinetics: Overview

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Nonlinear or dose-dependent pharmacokinetics is a phenomenon that occurs when the pharmacokinetic parameters of certain drugs deviate from linear pharmacokinetics at higher doses. These drugs do not follow the expected first-order kinetics, where the rate of drug elimination is directly proportional to the drug concentration. Instead, they exhibit a nonlinear relationship, which can be attributed to several factors.
Nonlinearity can arise due to the saturation of plasma protein-binding or...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis00:59

Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis

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Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
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Nonlinear Pharmacokinetics: Bioavailability and Protein-Drug Binding01:22

Nonlinear Pharmacokinetics: Bioavailability and Protein-Drug Binding

217
When a drug follows nonlinear pharmacokinetics, its bioavailability, the amount of the drug that reaches the systemic circulation, can change with different doses. This is due to the presence of a saturable pathway. The pathway becomes saturated as the drug concentration increases, decreasing the absorption rate. Consequently, the drug's bioavailability may be lower than expected at higher doses.
To quantify the extent of bioavailability, pharmacologists often use a parameter called .
217
Nonlinear Pharmacokinetics: Causes of Nonlinearity01:22

Nonlinear Pharmacokinetics: Causes of Nonlinearity

256
Nonlinearity in drug pharmacokinetics is caused by various factors influencing how a drug is absorbed, distributed, metabolized, and excreted. Understanding these nonlinear processes is crucial for predicting drug behavior in the body and optimizing drug dosing regimens.
Nonlinear drug absorption can occur when the process is rate-limited by solubility, carrier-mediated transport systems, or saturation of the presystemic gut wall or hepatic metabolism. For instance, high doses of riboflavin...
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A Student's Nontraditional Path to Pharmacy School.

Sarah Vreeburg1, Shadi Doroudgar2

  • 1Touro University California College of Pharmacy, Vallejo, CA, USA.

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|June 8, 2023
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Summary
This summary is machine-generated.

Pharmacy schools should consider admitting students with strong leadership and soft skills, not just high GPAs. This approach can help cultivate adaptable future pharmacists for evolving healthcare roles.

Keywords:
EnrollmentNontraditional studentPharmacy schoolRecruitment

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Area of Science:

  • Health Professions Education
  • Pharmacy Practice
  • Healthcare System Adaptation

Background:

  • Pharmacy school admissions heavily emphasize GPA and test scores.
  • There's a recognized need for pharmacists with leadership and soft skills to navigate healthcare changes.
  • National pharmacy school applications and enrollments have declined over the last decade.

Purpose of the Study:

  • To explore the value of admitting students with nontraditional backgrounds and soft skills into pharmacy programs.
  • To advocate for a potential shift in pharmacy school admissions strategies.

Main Methods:

  • Qualitative commentary based on a nontraditional student's pharmacy school experience.
  • Analysis of current trends in pharmacy education and the job market.

Main Results:

  • Nontraditional students can bring valuable leadership and soft skills to the pharmacy profession.
  • Adapting admissions criteria may help address declining enrollment and prepare pharmacists for future roles.

Conclusions:

  • Pharmacy programs may benefit from diversifying their applicant pool by considering attributes beyond traditional academic metrics.
  • Admissions committees should evaluate candidates for leadership potential and adaptability to meet evolving healthcare demands.