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Nicotinamide Adenine Dinucleotide (NAD
Mariana Bresque1, Daniel Esteve1, Mariana Pehar2,3
1Department of Neurology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Antioxidants & Redox Signaling
|June 8, 2023
Summary
Nicotinamide adenine dinucleotide (NAD+) decline impacts neuronal function and aging. Boosting NAD+ levels shows promise for treating neurological disorders by protecting against neuronal damage and improving cellular homeostasis.
Area of Science:
- Biochemistry
- Neuroscience
- Cellular Metabolism
Background:
- Nicotinamide adenine dinucleotide (NAD+) is crucial for redox reactions and signaling pathways.
- Imbalances in NAD+ synthesis and degradation are linked to neuronal dysfunction.
- NAD+ decline is observed in aging, a major risk factor for neurological disorders.
Purpose of the Study:
- To explore the role of NAD+ metabolism in neurological disorders.
- To investigate NAD+ as a therapeutic target for age-related and acute neuronal dysfunction.
- To understand how modulating NAD+ availability impacts cellular processes in the brain.
Main Methods:
- Review of current literature on NAD+ metabolism and neurological disorders.
- Analysis of studies investigating the effects of NAD+ modulation on neuronal health.
- Exploration of NAD+-dependent signaling pathways, including sirtuins.
Main Results:
- NAD+ decline is associated with aging and neurological conditions.
- Modulating NAD+ levels demonstrates protective effects against neuronal damage.
- Beneficial effects may stem from activating NAD+-dependent signaling pathways like sirtuins.
Conclusions:
- NAD+ metabolism is a promising therapeutic target for neurological disorders.
- Strategies to boost NAD+ availability may offer neuroprotection.
- Further research into cell-type-specific NAD+ targeting and sirtuin function is warranted.
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