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Modulating Copper Reactivity: A New Approach to Reprogram Mitochondrial Retrograde Signaling

Emmanouil Zacharioudakis1,2,3,4,5

  • 1Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States of America.

ACS Chemical Biology
|June 8, 2023
PubMed
Summary

Mitochondrial copper(II) accumulation in macrophages drives inflammation and reprogramming following infection. Targeting this copper(II) offers a new therapeutic strategy for controlling aberrant inflammation and cell plasticity.

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