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Genome Sequence of Lichtheimia ornata, an Emerging Opportunistic Mucorales Pathogen

Terrance Shea1, Jason T Mohabir1, Tania Kurbessoian2

  • 1Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

Microbiology Resource Announcements
|June 8, 2023
PubMed

Insights

Lichtheimia ornata, an emerging fungal pathogen, can cause fatal infections in immunocompromised individuals. This study presents the annotated genome sequence of an environmental Lichtheimia ornata isolate, CBS 291.66.

Area of Science:

  • Mycology
  • Genomics
  • Infectious Diseases

Background:

  • Lichtheimia ornata is an opportunistic fungal pathogen belonging to the order Mucorales.
  • It is increasingly associated with severe, often fatal, infections, particularly in immunocompromised patients.
  • Recent reports link it to mucormycosis cases, including those associated with coronavirus disease 2019 (COVID-19) in India.

Purpose of the Study:

  • To provide the first annotated genome sequence of an environmental isolate of Lichtheimia ornata.
  • To facilitate further research into the biology, pathogenicity, and antifungal resistance of this emerging pathogen.

Main Methods:

  • Whole-genome sequencing of the environmental isolate Lichtheimia ornata CBS 291.66.
  • Bioinformatic analysis for gene prediction, annotation, and comparative genomics.

Main Results:

  • The genome sequence of Lichtheimia ornata CBS 291.66 has been successfully assembled and annotated.
  • Key genes related to fungal growth, metabolism, and potential virulence factors have been identified.

Conclusions:

  • The availability of the annotated genome sequence represents a significant resource for understanding Lichtheimia ornata.
  • This genomic data will aid in developing diagnostic and therapeutic strategies against Lichtheimia ornata infections.

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