Orthopaedic applications of cold physical plasma

Area of Science:

• Orthopaedic research
• Biomaterial science
• Plasma medicine

Background:

• Cold physical plasma (CPP) has shown potential in various medical fields.
• Research on CPP in orthopaedics is limited compared to other specialties.
• Understanding CPP's interaction with musculoskeletal tissues is crucial.

Purpose of the Study:

• To review current research on CPP applications in orthopaedics.
• To explore CPP's role in biomaterial surface modification for osseointegration.
• To assess CPP's effects on musculoskeletal cells, tissues, and its therapeutic potential.

Main Methods:

• Review of existing literature on CPP in orthopaedics.
• Analysis of CPP's impact on biomaterial properties.
• Investigation of CPP's cellular and tissue-level effects, including safety.

Main Results:

• CPP is used for surface modification of orthopaedic implants to enhance osseointegration.
• CPP demonstrates bactericidal properties, beneficial for periprosthetic joint infections.
• CPP exhibits potential anticancerogenic and pro-apoptotic effects for bone lesions.

Conclusions:

• CPP presents significant promise for orthopaedic applications, including infection control and oncology.
• Further evidence-based research is essential for the safe and effective clinical implementation of CPP in orthopaedics.
• Balancing therapeutic benefits with potential adverse effects requires careful consideration.