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Updated: Jul 27, 2025

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
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Combination of GWAS and F

Le Wang1, Shadame Yeo1, May Lee1

  • 1Temasek Life Sciences Laboratory, National University of Singapore, 1 Research Link, Singapore, 117604, Singapore.

Molecular Genetics and Genomics : MGG
|June 8, 2023
PubMed
Summary

Researchers identified DNA markers for sugarcane traits like sugar content and pest resistance. This molecular breeding approach accelerates genetic improvement in sugarcane by enabling early selection of elite clones.

Keywords:
BreedingGBSGWASSNPSugarcane

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Area of Science:

  • Plant genetics
  • Agricultural science
  • Biotechnology

Background:

  • Sugarcane is vital for sugar and biofuel, but conventional breeding is slow.
  • Molecular breeding accelerates genetic gains using DNA markers for early selection.
  • Few DNA markers are currently identified for key sugarcane traits.

Purpose of the Study:

  • To identify DNA markers linked to sugar content, stalk diameter, and top borer resistance in sugarcane.
  • To leverage advanced sequencing and association studies for marker discovery.
  • To facilitate marker-assisted selection in sugarcane breeding programs.

Main Methods:

  • Genotyping of sugarcane samples using restriction site-associated DNA sequencing (RADseq).
  • Utilizing FST analysis and genome-wide association study (GWAS) for marker identification.
  • Analyzing DNA variants including single nucleotide polymorphisms (SNPs) and insertions/deletions (indels).

Main Results:

  • Identified 9 DNA variants associated with sugar content.
  • Discovered 23 DNA variants linked to stalk diameter.
  • Found 9 DNA variants associated with sugarcane top borer resistance.
  • Variants were located on different chromosomes, indicating complex inheritance.

Conclusions:

  • The identified DNA markers can accelerate sugarcane genetic improvement through early selection.
  • These markers hold potential for marker-assisted breeding programs.
  • Further validation of marker reliability in diverse populations is crucial before widespread application.