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Skeleton and Calcium Homeostasis

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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.

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Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

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Mucormycosis-induced hypercalcemia: a case report.

Larissa Araújo de Lucena¹, Fernanda Gurgel de Oliveira², Maíra Medeiros Pacheco de Andrade³

¹Department of Integrated Medicine, Federal University of Rio Grande do Norte, UFRN - HUOL, Nilo Peçanha Avenue, 620, 3rd underground - Petrópolis, Natal, RN, 59012-300, Brazil.

CEN Case Reports

|June 8, 2023

Summary

A rare case of hypercalcemia in a diabetic patient was linked to mucormycosis, a fungal infection. This finding highlights the importance of considering granulomatous diseases when diagnosing hypercalcemia, especially in immunocompromised individuals.

Area of Science:

Endocrinology
Infectious Diseases
Nephrology

Keywords:

Acute kidney injury Diabetic ketoacidosis Hypercalcemia Mucormycosis

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Background:

Hypercalcemia is a critical indicator of severe underlying conditions like cancer and infections.
While primary hyperparathyroidism and malignancies are common causes, granulomatous diseases, including fungal infections, can also lead to hypercalcemia.
The mechanism involves granulomatous tissue overproducing 1-alpha-hydroxylase, increasing vitamin D activation and subsequent calcium absorption.