Green synthesis of Au@g-C

Area of Science:

• Materials Science
• Electrochemistry
• Nanotechnology

Background:

• Vortioxetine (VOR) is an antidepressant requiring sensitive detection methods.
• Developing selective and stable electrochemical sensors is crucial for VOR analysis.
• Graphitic carbon nitride (g-C3N4) offers potential for electrochemical sensing applications.

Purpose of the Study:

• To develop a stable and green electrochemical sensor for selective vortioxetine (VOR) determination.
• To investigate the electrochemical properties of the Au@g-C3N4 nanocomposite for VOR detection.
• To evaluate the sensor's performance in pharmaceutical and biological samples.

Main Methods:

• Fabrication of Au@g-C3N4 nanocomposite on a glassy carbon electrode (GCE).
• Electrochemical characterization using cyclic voltammetry (CV), differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS), and chronoamperometry.
• Material characterization via X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX), Raman spectroscopy, and scanning electron microscopy (SEM).

Main Results:

• The Au@g-C3N4 nanocomposite exhibited enhanced conductivity and a narrower band gap compared to pure g-C3N4.
• The developed sensor showed high electrochemical activity for VOR detection with a low detection limit (LOD) of 3.2 nM.
• The sensor demonstrated ultrahigh selectivity for VOR, even in the presence of potential interferences in real samples.

Conclusions:

• The Au@g-C3N4/GCE is a highly selective, stable, and green electrochemical sensor for VOR determination.
• The enhanced electrochemical properties of the nanocomposite contribute to its superior sensing performance.
• This work provides insights into using phytosynthesized nanomaterials for advanced biosensing applications.