Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Mitochondria

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...

Current Trends in Nursing II

Current Trends in Nursing II

Trends in nursing are multifactorial and associated with changes in society, within the nursing profession, and in other professions. Notably, telehealth and remote nursing contribute to successful healthcare delivery for numerous patients and help reduce stress for nurses due to nursing shortages. Nurses can reach patients, monitor their conditions, and interact with them using computers, audio, visual accessories, and telephones—for example, remote patient monitoring systems. Likewise,...

Current Trends in Nursing I

Current Trends in Nursing I

Current trends in nursing include:

Issues And Trends In Healthcare Delivery System

Issues And Trends In Healthcare Delivery System

The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Protein Diffusion in Electroporation-Based Biopsy: Quantifying Protein Transport From Human Skin for Skin Liquid Sampling With Electroporation.

Biotechnology and bioengineering·2026

Same author

The organ-on-a-chip mirage: Animal replacement, plastic channels, and plastic claims: <i>The False Narrative Behind the War on Animal Research</i>.

Innovation and emerging technologies·2026

Same author

Mechanotyping of Organoids for Assessing Drug-Induced Injuries.

Advanced materials (Deerfield Beach, Fla.)·2025

Same author

Correction: Comparing two extracellular additives to facilitate extended storage of red blood cells in a supercooled state.

Frontiers in physiology·2025

Same author

Supercooled storage of red blood cells slows down the metabolic storage lesion.

Scientific reports·2025

Same author

Cryopreservable, scalable and ready-to-use cell-laden patches for diabetic ulcer treatment.

Bioactive materials·2025

Search research articles

Related Experiment Video

Updated: Jul 27, 2025

Techniques to Induce and Quantify Cellular Senescence

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

Current Trends in Anti-Aging Strategies.

Robert S Rosen¹, Martin L Yarmush¹

¹Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA;

Annual Review of Biomedical Engineering

|June 8, 2023

Summary

Aging is a complex biological process increasing disease risk. This review explores aging mechanisms, therapeutic strategies, and proposes a unifying approach for rigorous evaluation of anti-aging interventions.

Keywords:

aging anti-aging biological clocks progeria rejuvenation senescence

More Related Videos

Induction and Validation of Cellular Senescence in Primary Human Cells

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Related Experiment Videos

Last Updated: Jul 27, 2025

Techniques to Induce and Quantify Cellular Senescence

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

Induction and Validation of Cellular Senescence in Primary Human Cells

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Area of Science:

Gerontology and cellular biology, focusing on the biological mechanisms of aging.

Background:

Aging is a natural, complex process involving interconnected biological cascades leading to organismal degradation.
This process elevates the risk of numerous debilitating diseases, driving research into interventions.
Current therapeutic development is hampered by limited experimental validation and study design rigor.

Purpose of the Study:

To review the current understanding of aging mechanisms and their impact on experimental data interpretation.
To discuss promising therapeutic strategies for aging with potential clinical translation.
To propose a unifying framework for rigorously evaluating aging therapeutics.

Main Methods:

Literature review of current aging mechanisms.
Analysis of experimental models and their limitations in aging research.
Evaluation of existing and emerging therapeutic strategies for aging.

Main Results:

Aging is characterized by a complex network of biological processes.
Existing therapeutic strategies show promise in model systems but require further validation.
Current methodologies for therapeutic vetting are insufficient.

Conclusions:

A deeper understanding of aging mechanisms is crucial for interpreting experimental data.
Rigorous validation of therapeutic strategies is essential for clinical translation.
A unifying approach is needed to guide the development of effective anti-aging therapies.