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Current Trends in Anti-Aging Strategies
Robert S Rosen1, Martin L Yarmush1
1Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA;
Abstract:
The process of aging manifests from a highly interconnected network of biological cascades resulting in the degradation and breakdown of every living organism over time. This natural development increases risk for numerous diseases and can be debilitating. Academic and industrial investigators have long sought to impede, or potentially reverse, aging in the hopes of alleviating clinical burden, restoring functionality, and promoting longevity. Despite widespread investigation, identifying impactful therapeutics has been hindered by narrow experimental validation and the lack of rigorous study design. In this review, we explore the current understanding of the biological mechanisms of aging and how this understanding both informs and limits interpreting data from experimental models based on these mechanisms. We also discuss select therapeutic strategies that have yielded promising data in these model systems with potential clinical translation. Lastly, we propose a unifying approach needed to rigorously vet current and future therapeutics and guide evaluation toward efficacious therapies.
Insights
Aging is a complex biological process increasing disease risk. This review explores aging mechanisms, therapeutic strategies, and proposes a unifying approach for rigorous evaluation of anti-aging interventions.
Area of Science:
- Gerontology and cellular biology, focusing on the biological mechanisms of aging.
Background:
- Aging is a natural, complex process involving interconnected biological cascades leading to organismal degradation.
- This process elevates the risk of numerous debilitating diseases, driving research into interventions.
- Current therapeutic development is hampered by limited experimental validation and study design rigor.
Purpose of the Study:
- To review the current understanding of aging mechanisms and their impact on experimental data interpretation.
- To discuss promising therapeutic strategies for aging with potential clinical translation.
- To propose a unifying framework for rigorously evaluating aging therapeutics.
Main Methods:
- Literature review of current aging mechanisms.
- Analysis of experimental models and their limitations in aging research.
- Evaluation of existing and emerging therapeutic strategies for aging.
Main Results:
- Aging is characterized by a complex network of biological processes.
- Existing therapeutic strategies show promise in model systems but require further validation.
- Current methodologies for therapeutic vetting are insufficient.
Conclusions:
- A deeper understanding of aging mechanisms is crucial for interpreting experimental data.
- Rigorous validation of therapeutic strategies is essential for clinical translation.
- A unifying approach is needed to guide the development of effective anti-aging therapies.
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