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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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T Cell Types and Functions01:24

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Related Experiment Video

Updated: Jul 27, 2025

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CD32 Expression by CD4

Chun-Yan Yao1, Zhao-Suo Hu1, Run-Lin Yuan1

  • 1Department of Clinical Laboratory, the Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, China.

Viral Immunology
|June 8, 2023
PubMed
Summary
This summary is machine-generated.

Increased CD32 expression on CD4+ T and CD8+ T cells in chronic hepatitis B virus (HBV) infection may indicate liver injury severity. This finding suggests CD32 as a potential biomarker for assessing liver function impairment in HBV patients.

Keywords:
CD32chronic hepatitishepatitis B viruslymphocyte

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Area of Science:

  • Immunology
  • Hepatology
  • Virology

Background:

  • Fc gamma receptor (FcγR) plays a crucial role in immune responses, including those against hepatitis B virus (HBV).
  • CD32 is a key member of the FcγR family, involved in immune cell signaling and activation.
  • Understanding CD32 expression in chronic HBV infection is vital for assessing immune status and disease progression.

Purpose of the Study:

  • To investigate alterations in CD32 expression on CD4+ T and CD8+ T lymphocytes in patients with chronic HBV infection.
  • To evaluate the clinical utility of CD32 expression on T lymphocytes as a biomarker for liver injury severity in chronic HBV patients.

Main Methods:

  • Flow cytometry was used to measure the median fluorescence intensity (MFI) of CD32 expression on CD4+ T and CD8+ T lymphocytes.
  • A CD32 index was calculated for CD4+ T and CD8+ T lymphocytes.
  • Correlation analysis was performed between CD32 MFI and liver function indicators, such as serum aspartate aminotransferase.

Main Results:

  • CD32 MFI and the CD32 index were significantly elevated in chronic HBV patients compared to healthy controls.
  • In vitro stimulation of healthy lymphocytes with HBV-containing plasma led to increased CD32 expression.
  • A significant positive correlation was observed between CD32 MFI on CD4+ and CD8+ T cells and serum aspartate aminotransferase levels in HBV patients.

Conclusions:

  • Elevated CD32 expression on CD4+ and CD8+ T lymphocytes is associated with chronic HBV infection.
  • CD32 expression on T lymphocytes may serve as a promising biomarker for assessing the severity of liver function impairment in chronic HBV patients.