Related Experiment Video
Updated: Jul 27, 2025
Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
Published on: January 28, 2014
Molecular Biomarkers for Cardiometabolic Disease: Risk Assessment in Young Individuals
Usman A Tahir1, Robert E Gerszten1
1Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School.
Insights
Early detection of cardiometabolic disease risk in young adults is crucial. This review explores molecular biomarkers and omics technologies for improved risk assessment in this population.
Area of Science:
- Cardiology
- Metabolic Health
- Preventive Medicine
Background:
- Cardiometabolic diseases (cardiovascular disease and diabetes) are leading causes of death globally.
- Recent trends show stalled declines in cardiovascular disease and rising risk factors in young adults.
- Early risk assessment is vital for this demographic.
Purpose of the Study:
- To review molecular biomarkers for early cardiometabolic disease risk assessment in young individuals.
- To evaluate traditional and novel biomarkers.
- To explore omics technologies for enhanced risk prediction.
Main Methods:
- Literature review of existing studies on cardiometabolic disease biomarkers.
- Analysis of traditional and emerging molecular markers.
- Examination of omics technologies (genomics, proteomics, metabolomics) and analytical methods.
Main Results:
- Traditional biomarkers have limitations in young populations.
- Novel biomarkers targeting specific early disease pathways show promise.
- Omics technologies offer potential for comprehensive risk profiling.
Conclusions:
- There is a need for advanced risk assessment strategies in young adults.
- Molecular biomarkers and omics approaches are key to early detection.
- Further research can refine these tools for clinical application.
Abstract:
Cardiometabolic diseases, including cardiovascular disease and diabetes, are major causes of morbidity and mortality worldwide. Despite progress in prevention and treatment, recent trends show a stalling in the reduction of cardiovascular disease morbidity and mortality, paralleled by increasing rates of cardiometabolic disease risk factors in young adults, underscoring the importance of risk assessments in this population. This review highlights the evidence for molecular biomarkers for early risk assessment in young individuals. We examine the utility of traditional biomarkers in young individuals and discuss novel, nontraditional biomarkers specific to pathways contributing to early cardiometabolic disease risk. Additionally, we explore emerging omic technologies and analytical approaches that could enhance risk assessment for cardiometabolic disease.
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:30Coronary Artery Disease I: Introduction