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Updated: Jul 27, 2025

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Formal [4 + 2] Cycloadditions of Maleimides on Duplex DNA

Kaleena Basran1, Anna Bujalska2, Ashkan Karimi1

  • 1Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, Quebec H3A 0B8, Canada.

Bioconjugate Chemistry
|June 8, 2023
PubMed
Summary

This study reveals distinct reaction mechanisms for DNA bioconjugation using vinyl-deoxyuridine (VdU) and butadienyl-deoxyuridine (BDdU) with maleimides, enabling efficient DNA labeling in vitro and in cells.

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