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Severity outcomes associated with SARS-CoV-2 XBB variants, an observational analysis
Eili Y Klein1, Amary Fall2, Julie M Norton2
1Department of Emergency Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD, USA; One Health Trust, Washington, DC, USA.
Abstract:
The rapidity with which SARS-CoV-2 XBB variants rose to predominance has been alarming. We used a large cohort of patients diagnosed with Omicron infections between September 2022 and mid-February 2023 to evaluate the likelihood of admission or need for supplemental oxygen in patients infected with XBB variants. Our data showed no significant association between XBB or XBB.1.5 infections and admissions. Older age groups, lack of vaccination, immunosuppression and underlying heart, kidney, and lung disease showed significant associations with hospitalization.
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