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Published on: April 8, 2016
Prostate-Specific Membrane Antigen Uptake Heterogeneity in Mixed Ductal-Acinar Adenocarcinoma of the Prostate
Qian Zhao1, Aisheng Dong2, Yushu Bai3
1From the Department of Nuclear Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia.
Abstract:
Prostate-specific membrane antigen (PSMA) PET findings of mixed ductal-acinar adenocarcinoma of the prostate are rarely reported. We describe 18 F-PSMA-1007 PET/CT and delayed pelvic 18 F-PSMA-1007 PET/MRI findings in a case of prostatic mixed ductal-acinar adenocarcinoma with multiple lymph node and bone metastases. The primary tumor showed heterogeneous PSMA uptake. The metastases in the right ilium and acetabulum showed intense PSMA uptake, but the pelvic lymph node and left iliac bone metastases showed no significant PSMA uptake. Knowledge of the intraprimary and intermetastatic heterogeneity of PSMA uptake in mixed ductal-acinar adenocarcinoma of the prostate may be helpful for accurate interpretation.
Insights
Prostate-specific membrane antigen (PSMA) PET imaging reveals varied uptake in mixed ductal-acinar adenocarcinoma. This heterogeneity in primary tumors and metastases is crucial for accurate interpretation of PSMA PET scans.
Area of Science:
- Nuclear Medicine
- Oncology
- Radiology
Background:
- Prostate-specific membrane antigen (PSMA) PET imaging is increasingly used for prostate cancer detection and staging.
- Mixed ductal-acinar adenocarcinoma is a rare subtype of prostate cancer.
- Limited data exists on PSMA PET findings in this specific histological variant.
