Integrating domain knowledge for biomedical text analysis into deep learning: A survey

The past decade has witnessed an explosion of textual information in the biomedical field. Biomedical texts provide a basis for healthcare delivery, knowledge discovery, and decision-making. Over the same period, deep learning has achieved remarkable performance in biomedical natural language processing, however, its development has been limited by well-annotated datasets and interpretability. To solve this, researchers have considered combining domain knowledge (such as biomedical knowledge graph) with biomedical data, which has become a promising means of introducing more information into biomedical datasets and following evidence-based medicine. This paper comprehensively reviews more than 150 recent literature studies on incorporating domain knowledge into deep learning models to facilitate typical biomedical text analysis tasks, including information extraction, text classification, and text generation. We eventually discuss various challenges and future directions.