Evaluation of electroretinography (ERG) parameters as a biomarker for ADHD
Marc-André Dubois1, Charles-Antoine Pelletier2, Chantal Mérette3
1CERVO Brain Research Centre, Centre Intégré Universitaire de Santé et des Services Sociaux de la Capitale Nationale, Quebec, QC, Canada; School of Psychology, Faculty of Social Sciences, Université Laval, Quebec, QC, Canada.
Background:
The retina is recognized as an accessible part of the brain due to their common embryonic origin. The electroretinogram (ERG) has proven to be a valuable tool for detecting schizophrenia and bipolarity. We therefore investigated its ability to detect ADHD.
Methods:
The cone and rod luminance response functions of the ERG were recorded in 26 ADHD subjects (17 women and 9 men) and 25 controls (16 women and 9 men).
Results:
No significant differences were found between the mixed groups, but sexual dysmorphia was observed in the significant results. In males, a significant prolonged cone a-wave latency was observed in the ADHD group. In females, we observed a significant decrease in the cone a- and b-wave amplitudes and a trend for a prolonged cone b-wave latency as well as a higher scotopic mixed rod-cone a-wave in the ADHD group.
Conclusion:
The data obtained in this study show the potential of the ERG to detect ADHD, warranting further large-scale studies.
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