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Targeting lymphoid-derived IL-17 signaling to delay skin aging

Paloma Solá1, Elisabetta Mereu2, Júlia Bonjoch1

  • 1Institute for Research in Biomedicine, Barcelona Institute of Science and Technology, Barcelona, Spain.

Nature Aging
|June 8, 2023
PubMed

Insights

Aging skin exhibits chronic inflammation driven by increased IL-17 signaling. Blocking this pathway in mice delayed skin aging, suggesting a therapeutic target for age-related skin conditions.

Area of Science:

  • Immunology
  • Dermatology
  • Aging Research

Background:

  • Skin aging involves structural and functional decline, linked to local niche alterations and stem cell changes.
  • Pro-inflammatory microenvironments significantly influence age-associated frailty and tissue aging.
  • The specific inflammatory cues and their impact on skin aging remain largely unknown.

Purpose of the Study:

  • To investigate the nature of age-associated inflammatory cues in mouse skin.
  • To determine the role of IL-17 (interleukin-17) signaling in skin aging.
  • To explore IL-17 blockade as a potential strategy to mitigate skin aging.

Main Methods:

  • Single-cell RNA sequencing of the dermal compartment in aged mouse skin.
  • In vivo blockade of IL-17 signaling during the aging process.
  • Analysis of NF-κB signaling pathways in epidermal cells.

Main Results:

  • Aged mouse skin shows a higher prevalence of IL-17-expressing T helper cells, γδ T cells, and innate lymphoid cells.
  • In vivo IL-17 blockade reduced skin inflammation and delayed the onset of age-related skin traits.
  • Aberrant IL-17 signaling activates NF-κB in epidermal cells, impairing homeostasis and promoting inflammation.

Conclusions:

  • Aged skin is characterized by chronic inflammation, with IL-17 playing a key role.
  • Targeting IL-17 signaling presents a promising therapeutic avenue for preventing age-associated skin ailments.
  • Understanding IL-17's mechanism in epidermal cells offers insights into skin aging processes.

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