CFD analysis on blood flow inside a symmetric stenosed artery: Physiology of a coronary artery disease

Salman Akhtar1, Zahir Hussain2, Sohail Nadeem1,3

  • 1Department of Mathematics, Quaid-i-Azam University, Islamabad, Pakistan.

Science Progress
|June 9, 2023
PubMed

Insights

Computational fluid dynamics (CFD) reveals how blood flow changes in a stenosed coronary artery. Velocity increases before the stenosis and decreases after, impacting blood flow dynamics in coronary artery disease.

Area of Science:

  • Biomedical Engineering
  • Fluid Dynamics
  • Cardiovascular Research

Background:

  • Coronary artery disease (CAD) involves arterial narrowing, affecting blood flow.
  • Accurate modeling of blood flow in stenosed arteries is crucial for understanding CAD progression.
  • Symmetric stenosis in the left coronary artery is a common pathological feature.

Purpose of the Study:

  • To numerically analyze blood flow dynamics within a symmetrically stenosed left coronary artery.
  • To investigate the impact of stenosis on velocity and pressure profiles using computational fluid dynamics (CFD).
  • To provide a detailed graphical analysis of blood flow alterations caused by coronary artery disease.

Main Methods:

  • Utilized the Open-Field Operation And Manipulation (OpenFOAM) CFD toolbox for numerical simulations.
  • Modeled blood flow as unsteady, laminar, and incompressible, using the non-Newtonian Casson fluid model.
  • Analyzed dimensional flow characteristics, including velocity and pressure profiles, and streamlines in pre-stenosis, stenosis, and post-stenosis regions.

Main Results:

  • Observed an increase in blood flow velocity in the pre-stenosis region with increasing axial length.
  • Documented a decrease in blood flow velocity in the post-stenosis region with increasing axial length.
  • Demonstrated alterations in flow profiles, with velocity rising towards the stenosis and falling thereafter.

Conclusions:

  • CFD analysis effectively illustrates the hemodynamic changes associated with coronary artery stenosis.
  • The study highlights significant variations in velocity profiles before and after the stenotic region.
  • Findings contribute to a better understanding of blood flow mechanics in diseased coronary arteries.

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