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CFD analysis on blood flow inside a symmetric stenosed artery: Physiology of a coronary artery disease
Salman Akhtar1, Zahir Hussain2, Sohail Nadeem1,3
1Department of Mathematics, Quaid-i-Azam University, Islamabad, Pakistan.
Insights
Computational fluid dynamics (CFD) reveals how blood flow changes in a stenosed coronary artery. Velocity increases before the stenosis and decreases after, impacting blood flow dynamics in coronary artery disease.
Area of Science:
- Biomedical Engineering
- Fluid Dynamics
- Cardiovascular Research
Background:
- Coronary artery disease (CAD) involves arterial narrowing, affecting blood flow.
- Accurate modeling of blood flow in stenosed arteries is crucial for understanding CAD progression.
- Symmetric stenosis in the left coronary artery is a common pathological feature.
Purpose of the Study:
- To numerically analyze blood flow dynamics within a symmetrically stenosed left coronary artery.
- To investigate the impact of stenosis on velocity and pressure profiles using computational fluid dynamics (CFD).
- To provide a detailed graphical analysis of blood flow alterations caused by coronary artery disease.
Main Methods:
- Utilized the Open-Field Operation And Manipulation (OpenFOAM) CFD toolbox for numerical simulations.
- Modeled blood flow as unsteady, laminar, and incompressible, using the non-Newtonian Casson fluid model.
- Analyzed dimensional flow characteristics, including velocity and pressure profiles, and streamlines in pre-stenosis, stenosis, and post-stenosis regions.
Main Results:
- Observed an increase in blood flow velocity in the pre-stenosis region with increasing axial length.
- Documented a decrease in blood flow velocity in the post-stenosis region with increasing axial length.
- Demonstrated alterations in flow profiles, with velocity rising towards the stenosis and falling thereafter.
Conclusions:
- CFD analysis effectively illustrates the hemodynamic changes associated with coronary artery stenosis.
- The study highlights significant variations in velocity profiles before and after the stenotic region.
- Findings contribute to a better understanding of blood flow mechanics in diseased coronary arteries.
Abstract:
This research article interprets the computational fluid dynamics analysis on blood flow inside a symmetric stenosed artery. The current problem models the blood flow inside the left coronary artery as having a symmetric stenosis in the central region. A comprehensive physiological examination of coronary artery disease is numerically evaluated by using the computational fluid dynamics toolbox Open-Field Operation And Manipulation. There are no assumptions of mild stenosis taken into account since the considered stenosis has an exactly measured length, height and position, etc. The blood flow problem is modeled for the non-Newtonian Casson fluid with unsteady, laminar, and incompressible flow assumptions. The underlying problem is solved numerically in its dimensional form. A thorough graphical analysis is provided on the blood flow simulations, pressure profile, velocity line graphs, pressure line graphs, and streamlines for the left coronary artery having a symmetric stenosis formation. The considered artery is divided into three sections, i.e. pre-stenosis, post-stenosis, and stenosis region, and the velocity and pressure line graphs are plotted for these considered regions. The graphical illustrations provide a detailed analysis of how the blood flow is affected inside the left coronary artery due to coronary artery disease. These pre- and post-stenosis velocity line graphs reveal two intriguing results: In the pre-stenosis zone, the velocity increases with increasing axial coordinate length, whereas in the post-stenosis region, the velocity decreases with rising axial coordinate length. It is evident that as the flow moves toward the stenosis region, the flow profile rises; yet, after passing through the stenosis zone, the flow profile begins to fall as the flow moves away from the stenosis region.
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