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Related Experiment Videos

A fiberoptic reflection densitometer with cardiac output calculator.

M L Landsman, N Knop, G A Mook

    Pflugers Archiv : European Journal of Physiology
    |February 14, 1979
    PubMed
    Summary

    A new catheter-tip densitometer accurately measures indocyanine green dye concentration in blood. This device enables precise cardiac output calculations, improving diagnostic capabilities for cardiovascular conditions.

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    Area of Science:

    • Biomedical Engineering
    • Medical Devices
    • Cardiovascular Diagnostics

    Background:

    • Accurate measurement of indocyanine green (ICG) dye concentration is crucial for cardiovascular diagnostics.
    • Existing methods for ICG quantification can be affected by physiological variations like blood flow and hemoglobin concentration.
    • A reliable and integrated system for real-time ICG measurement and cardiac output calculation is needed.

    Purpose of the Study:

    • To describe a novel catheter-tip densitometer for measuring indocyanine green in blood.
    • To evaluate the performance of the densitometer in relation to dye concentration, hemoglobin levels, and oxygen saturation.
    • To integrate the densitometer with a cardiac output calculator for a comprehensive cardiovascular assessment.

    Main Methods:

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  • Development of a cardiac catheter incorporating optical fibers, an incandescent light source, and a detection/processing unit.
  • Utilizing back-scattered light measurement with specific optical filters (800 nm, 920 nm, or 950 nm) based on fiber type (glass or plastic).
  • Incorporation of an analog cardiac output calculator with an integrator and divider for real-time calculations.

    • Main Results:

    • The densitometer exhibits a linear relationship between output and ICG concentration up to 50 mg/L.
    • Compensation for blood flow variations is significantly improved compared to previous methods.
    • The system demonstrates relative insensitivity to hemoglobin concentration at zero dye concentration, but considerable influence when dye is present.
    • Output is affected by oxygen saturation, though the calibration slope remains stable.

    Conclusions:

    • The developed catheter-tip densitometer provides a reliable method for quantifying indocyanine green in blood.
    • The integrated system allows for accurate real-time cardiac output determination.
    • This technology offers potential for enhanced cardiovascular monitoring and diagnosis.