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An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
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Association Between Intestinal

Juan Liu1, Liang Zhou1, Lili Sun1

  • 1Department of Endocrinology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, 213164, People's Republic of China.

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
|June 9, 2023
PubMed
Summary
This summary is machine-generated.

Reduced Prevotella copri in brittle diabetes mellitus (BDM) patients correlates with increased blood glucose fluctuations. This finding suggests a link between gut bacteria and glycemic variability in BDM, impacting diabetes management.

Keywords:
Prevotella copribrittle diabetescase-control studyglycemic variabilitytype 2 diabetes mellitus

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Area of Science:

  • Microbiome research
  • Metagenomics
  • Diabetes mellitus

Background:

  • Gut microbiota composition is linked to type 2 diabetes pathogenesis.
  • The relationship between intestinal Prevotella copri and glycemic fluctuations in brittle diabetes mellitus (BDM) is not well understood.

Purpose of the Study:

  • To investigate the correlation between intestinal Prevotella copri abundance and glycemic fluctuations in BDM patients.
  • To compare gut microbiota composition between BDM and non-brittle type 2 diabetes mellitus (NBT2DM) patients.

Main Methods:

  • Case-control study comparing BDM and NBT2DM patients.
  • Metagenomic analysis of fecal samples to assess gut microbiome composition.
  • Correlation analysis between Prevotella copri abundance and glycemic variability metrics (e.g., standard deviation of blood glucose).

Main Results:

  • Significant differences in gut microbiota beta diversity between BDM and NBT2DM groups.
  • Lower abundance of Bacteroidetes phylum and Prevotella copri in BDM patients.
  • Inverse correlation between Prevotella copri abundance and standard deviation of blood glucose (SDBG) in BDM patients.

Conclusions:

  • Decreased intestinal Prevotella copri abundance in BDM patients is associated with increased glycemic fluctuations.
  • Prevotella copri may play a role in the glycemic variability observed in brittle diabetes mellitus.