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Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
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Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
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Adrenergic Agonists: Therapeutic Classification01:18

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Adrenergic agonists can be classified based on their therapeutic uses and mechanisms of action. They serve various purposes in clinical applications.
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Drugs that mimic the action of endogenous catecholamines like noradrenaline and adrenaline are called adrenergic agonists or sympathomimetics. Based on their mechanism of action, sympathomimetics can be classified as direct-, indirect-, or mixed-acting sympathomimetics. Direct-acting adrenergic agonists activate adrenoceptors without affecting presynaptic neurons, making them independent of neuronal catecholamine-depleting agents like reserpine and guanethidine.
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β-adrenergic antagonists, or β-blockers, modulate the sympathetic nervous system by targeting β-adrenoceptors and inhibiting catecholamine-mediated sympathetic responses. β-blockers differ in their adrenoceptor subtype affinity, lipophilicity, and α-blocking capabilities. The history of β-blocker development began with the prototype, dichloroisoprenaline, which exhibited partial agonist activity. As a result, propranolol was developed as a pure antagonist but...
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Short-acting β

Andrea Yu-Lin Ban1, Paranthaman Vengadasalam2, Sri Wahyu Taher3

  • 1MB Bch BAO (Ireland), MMed (UKM), Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Kuala Lumpur, Malaysia.

Malaysian Family Physician : the Official Journal of the Academy of Family Physicians of Malaysia
|June 9, 2023
PubMed
Summary
This summary is machine-generated.

High short-acting β2-agonist (SABA) over-prescription in Malaysia is linked to poorer asthma control and more severe exacerbations. This highlights an urgent need for updated clinical guidelines and policy interventions to improve asthma management.

Keywords:
AsthmaAsthma controlMalaysiaSevere exacerbationsShort-acting β2-agonist

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Area of Science:

  • Pulmonology
  • Pharmacology
  • Public Health

Background:

  • Short-acting β2-agonist (SABA) overuse is a global concern in asthma management.
  • Understanding SABA prescription patterns and their clinical impact in diverse healthcare settings is crucial.

Purpose of the Study:

  • To evaluate SABA prescription patterns in Malaysia.
  • To investigate the association between SABA prescription frequency and asthma control and severe exacerbations within the SABINA III cohort.

Main Methods:

  • An observational, cross-sectional study of 731 patients (≥12 years) in Malaysian primary and specialty care centers.
  • Data collected on prescribed asthma treatments, SABA prescriptions, and asthma symptom control.
  • Multivariable regression models analyzed associations between SABA prescription and asthma outcomes.

Main Results:

  • A high prevalence of SABA over-prescription (≥3 prescriptions/year) was observed (47.4%).
  • Nearly 10% of patients purchased SABA without a prescription, with a significant proportion buying multiple inhalers.
  • Prescribing ≥3 SABA inhalers was associated with lower odds of partly controlled asthma and higher odds of severe exacerbations.

Conclusions:

  • SABA over-prescription is a significant issue in Malaysia across different healthcare settings.
  • Findings underscore the necessity for healthcare providers and policymakers to implement evidence-based recommendations to mitigate SABA overuse.
  • Addressing SABA over-prescription is critical for improving asthma control and reducing exacerbations in Malaysia.