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In vivo antidiabetic effects of phenolic compounds of spinach, mustard, and cabbage leaves in mice.

Arif Mehmood1, Alam Zeb2, Muhammad Khalil Ateeq3

  • 1Department of Biotechnology, University of Malakand, Chakdara, Khyber Pakhtunkhwa, Pakistan.

Heliyon
|June 9, 2023
PubMed
Summary
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Leafy vegetables like spinach, mustard, and cabbage contain phenolic compounds that show antidiabetic effects. These vegetable extracts improved key health indicators in diabetic mice, with cabbage being particularly effective.

Area of Science:

  • Nutritional Science
  • Biochemistry
  • Pharmacology

Background:

  • Bioactive phenolic compounds in leafy vegetables contribute to their health benefits.
  • Diabetes mellitus is a metabolic disorder with significant health implications.
  • Alloxan-induced diabetic mice are a common model for studying antidiabetic agents.

Purpose of the Study:

  • To investigate the antidiabetic effects of phenolic-rich aqueous extracts from spinach, mustard, and cabbage.
  • To evaluate the impact of these extracts on biochemical, antioxidant, hematological, and histopathological indices in diabetic mice.

Main Methods:

  • Phenolic compounds were identified and quantified using High-Performance Liquid Chromatography with Diode-Array Detection (HPLC-DAD).
  • Aqueous extracts of spinach, mustard, and cabbage were administered to alloxan-induced diabetic mice.
Keywords:
Antidiabetic potentialCabbageDiabetesMustardPhenolic compoundsSpinach

Related Experiment Videos

  • Various physiological and biochemical parameters were assessed, including body weight, fasting blood sugar, liver and renal function tests, lipid profile, glutathione levels, hematology, and tissue histology.

    • Main Results:

    • Ten, nineteen, and eleven phenolic compounds were identified in spinach, mustard, and cabbage extracts, respectively.
    • Diabetic mice showed significant improvements in body weight, fasting blood sugar, liver and renal function, and lipid profiles after treatment.
    • Antioxidant status (tissue total glutathione), hematological indices, and tissue histology also demonstrated recovery from diabetic stress in treated groups.
    • Cabbage extract exhibited a comparatively stronger effect in ameliorating diabetic stress among the tested vegetables.

    Conclusions:

    • The selected leafy vegetables, rich in phenolic compounds, possess significant potential to mitigate diabetic complications.
    • These findings support the traditional use of leafy vegetables for health promotion and offer a basis for developing novel antidiabetic therapies.