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Anette Gjörloff Wingren1,2, Riyam Ziyad Faik1,2, Anna Holefors3

  • 1Department of Biomedical Science, Faculty of Health and Society, Malmö University, Malmö, Sweden.

Heliyon
|June 9, 2023
PubMed
Summary

Plant extracts from Silybum marianum show significant antioxidant and anti-inflammatory properties. These findings suggest potential for controlling skin cancer progression by suppressing pro-inflammatory cytokines like IL-6.

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Area of Science:

  • Phytochemistry
  • Dermatology
  • Pharmacology

Background:

  • Skin cancer incidence is rising globally, necessitating novel therapeutic strategies.
  • Plant-derived flavonoids offer potential for controlling tumor initiation and progression by suppressing pro-inflammatory cytokines.
  • This study investigates the anti-inflammatory and antioxidant potential of specific plant callus extracts in skin cells.

Purpose of the Study:

  • To evaluate the antioxidant and anti-inflammatory activities of undifferentiated callus extracts from Plantago major, Silybum marianum, and Rhodiola rosea.
  • To assess the effect of these extracts on pro-inflammatory cytokine (IL-6) production in normal and malignant skin cells.
  • To identify the plant extract with the most potent anti-inflammatory and antioxidant properties.

Main Methods:

Keywords:
Anti-inflammatoryAntioxidantFlavonoidHPTLCInterleukin-6KeratinocytesPlantago major LTroloxUndifferentiated callus extracts

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  • Antioxidant capacity was determined using the Trolox Equivalent Antioxidant Capacity (TEAC) assay.
  • Phytochemical profiles were analyzed using High-Performance Thin-Layer Chromatography (HPTLC).
  • Anti-inflammatory effects were assessed by measuring the suppression of induced Interleukin-6 (IL-6) production in skin cells and keratinocytes via Enzyme-Linked Immunosorbent Assay (ELISA).

Main Results:

  • HPTLC confirmed complex phytochemical profiles rich in phenolic and flavonoid compounds in all extracts.
  • Silybum marianum extract demonstrated the most significant inhibition of induced IL-6 production in both normal keratinocytes and malignant skin cells.
  • Silybum marianum extract exhibited the highest flavonoid content and the strongest antioxidant activity among the tested extracts.

Conclusions:

  • Undifferentiated callus extracts of Silybum marianum possess significant antioxidant and anti-inflammatory properties.
  • These extracts effectively suppress pro-inflammatory IL-6 production in both normal and malignant keratinocytes.
  • Silybum marianum extracts represent a promising natural agent for managing skin inflammation and potentially controlling skin cancer progression.