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Published on: August 11, 2015
Endovascular management of intracranial aneurysms at Chris Hani Baragwanath Academic Hospital
Herchel Clarke1, Trevor Nefale1, Victor Mngomezulu1
1Department of Radiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Insights
Endovascular treatment for intracranial aneurysms is effective, with rupture occurring at smaller sizes. This study highlights key patient and aneurysm characteristics in a resource-limited setting.
Area of Science:
- Neurosurgery
- Interventional Neuroradiology
- Vascular Neurology
Background:
- Intracranial aneurysms pose a significant global mortality risk.
- Endovascular management is a preferred treatment for select patients.
- Patient demographics and aneurysm characteristics vary across populations.
Purpose of the Study:
- To investigate the profile of patients with intracranial aneurysms undergoing endovascular treatment.
- To analyze patient demographics, risk factors, indications, and aneurysm characteristics.
- To assess intra-operative complications in a specific healthcare setting.
Main Methods:
- Retrospective study over three years (January 2018 - January 2021).
- Inclusion of all adult patients undergoing endovascular management.
- Statistical analysis using the Chi-square test for categorical variables.
Main Results:
- 77 patients included; mean age 47 ± 11.6 years; male-to-female ratio 1:1.8.
- Hypertension was the most common risk factor (27%).
- Ruptured aneurysms, small neck size (<4mm), and internal cerebral artery (ICA) locations showed statistical significance (p=0.020, p=0.010, p=0.001 respectively).
Conclusions:
- Findings align with known female preponderance and anterior circulation aneurysm prevalence.
- Endovascular management demonstrated a low complication rate.
- Intracranial aneurysms were observed to rupture at smaller dimensions.
Background:
Worldwide, intracranial aneurysms are associated with a high mortality rate. While endovascular management has proven to be the choice of treatment in selected patients, patient demographics and aneurysm characteristics differ between study populations.
Objectives:
This study aimed to investigate the profile of patients with intracranial aneurysms who underwent endovascular management in the Interventional Neuroradiology Unit at Chris Hani Baragwanath Academic Hospital. Patient demographics, risk factors, indications, aneurysm characteristics and intra-operative complications were studied.
Method:
This was a 3-year retrospective study of all adult patients between 01 January 2018 and 31 January 2021. The Chi-square test was used to compare categorical variables.
Results:
A total of 77 patients were included in this study. The mean age of the patients was 47 ± 11.6 with a male-to-female ratio of 1:1.8. Hypertension was the most reported risk factor in 27% of patients. There was no statistical correlation between the gender groups according to presentation, multiplicity, aneurysmal size dimensions and locations. According to the presentation, there was statistical significance in ruptured intracranial aneurysms (p = 0.020), neck size dimensions less than 4 mm (p = 0.010), and aneurysms located in the internal cerebral artery (ICA) circulation (p = 0.001).
Conclusion:
The study findings support known parameters including females and anterior circulation aneurysm preponderance, and the low complication risk of endovascular management. Interestingly, intracranial aneurysms presented with rupture at smaller size dimensions.
Contribution:
This study provides valuable insights into intracranial aneurysm characteristics and endovascular management efficacy in a resource-limited setting.
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