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[Post-COVID-19 syndrome].

David Montani1, Laurent Savale1, Nicolas Noel2

  • 1Université Paris-Saclay, AP-HP, service de pneumologie et soins intensifs respiratoires, hôpital de Bicêtre, DMU 5 Thorinno, Inserm UMR_S999, Le Kremlin-Bicêtre, France.

Bulletin De L'Academie Nationale De Medecine
|June 9, 2023
PubMed
Summary
This summary is machine-generated.

Long COVID-19, or post-acute COVID-19 syndrome, affects many patients with persistent symptoms like fatigue and dyspnea. While most symptoms improve over time, vaccination may reduce incidence.

Keywords:
AnxietyCoronavirus infectionsDepressionDyspneaLong-term adverse effectsPulmonary fibrosisSARS virus

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Area of Science:

  • Infectious Diseases
  • Pulmonology
  • Neurology

Context:

  • Post-acute sequelae of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection, termed long COVID-19, present a significant clinical challenge.
  • High incidence observed, with up to 50% of patients experiencing symptoms 4-6 months post-infection.
  • Symptoms affect multiple organ systems, impacting patient quality of life and healthcare systems.

Purpose:

  • To review the multifaceted nature of long COVID-19 syndrome.
  • To outline common and rarer persistent symptoms and their potential contributing factors.
  • To discuss the current understanding of pathophysiology and the role of vaccination.

Summary:

  • Persistent fatigue and dyspnea are the most common symptoms, alongside frequent cognitive and psychological disorders (anxiety, depression, PTSD).
  • Radiological pulmonary sequelae are infrequent, but functional respiratory issues are common.
  • Cardiac, endocrine, cutaneous, digestive, and renal sequelae are less common. Symptoms generally improve over months, but long-term prevalence remains notable.

Impact:

  • Long COVID-19 represents a substantial public health challenge due to the large number of affected individuals.
  • Understanding symptom prevalence, risk factors (initial illness severity, female sex), and pathophysiology is crucial for management.
  • Vaccination appears to decrease the incidence of long COVID-19, highlighting its preventive role.