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Updated: Jul 27, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
Published on: December 19, 2020
[Post-COVID-19 syndrome]
David Montani1, Laurent Savale1, Nicolas Noel2
1Université Paris-Saclay, AP-HP, service de pneumologie et soins intensifs respiratoires, hôpital de Bicêtre, DMU 5 Thorinno, Inserm UMR_S999, Le Kremlin-Bicêtre, France.
Long COVID-19, or post-acute COVID-19 syndrome, affects many patients with persistent symptoms like fatigue and dyspnea. While most symptoms improve over time, vaccination may reduce incidence.
Area of Science:
- Infectious Diseases
- Pulmonology
- Neurology
Context:
- Post-acute sequelae of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection, termed long COVID-19, present a significant clinical challenge.
- High incidence observed, with up to 50% of patients experiencing symptoms 4-6 months post-infection.
- Symptoms affect multiple organ systems, impacting patient quality of life and healthcare systems.
Purpose:
- To review the multifaceted nature of long COVID-19 syndrome.
- To outline common and rarer persistent symptoms and their potential contributing factors.
- To discuss the current understanding of pathophysiology and the role of vaccination.
Summary:
- Persistent fatigue and dyspnea are the most common symptoms, alongside frequent cognitive and psychological disorders (anxiety, depression, PTSD).
- Radiological pulmonary sequelae are infrequent, but functional respiratory issues are common.
- Cardiac, endocrine, cutaneous, digestive, and renal sequelae are less common. Symptoms generally improve over months, but long-term prevalence remains notable.
Impact:
- Long COVID-19 represents a substantial public health challenge due to the large number of affected individuals.
- Understanding symptom prevalence, risk factors (initial illness severity, female sex), and pathophysiology is crucial for management.
- Vaccination appears to decrease the incidence of long COVID-19, highlighting its preventive role.
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