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Related Concept Videos

Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Myocarditis I: Introduction01:21

Myocarditis I: Introduction

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Pericarditis I: Introduction01:22

Pericarditis I: Introduction

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Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
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Endocarditis I: Introduction01:25

Endocarditis I: Introduction

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Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
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Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

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Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
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Related Experiment Video

Updated: Jul 27, 2025

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
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IgA Vasculitis Associated With COVID-19.

Yousef Salem1, Zaryab Alam2, Mojahed M Shalabi3

  • 1Department of Dermatology, University of Texas Health Science Center at San Antonio, San Antonio, USA.

Cureus
|June 9, 2023
PubMed
Summary
This summary is machine-generated.

IgA vasculitis (Henoch-Schonlein Purpura) is a rare COVID-19 complication. This case highlights a young woman with a rash, shortness of breath, and confirmed IgA vasculitis during COVID-19 infection.

Keywords:
covid-19dermatopathologyhenoch-schonlein purpuraiga vasculitisvasculitis

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Area of Science:

  • Immunology
  • Rheumatology
  • Infectious Diseases

Background:

  • IgA vasculitis (Henoch-Schonlein Purpura) is a systemic small vessel vasculitis.
  • While commonly seen in children post-infection, it affects all ages and can be linked to drugs or vaccines.
  • COVID-19 has diverse clinical presentations, including rare dermatological manifestations.

Observation:

  • A 21-year-old female presented with a petechial rash and dyspnea.
  • Initial COVID-19 testing was negative; she received prednisone.
  • Worsening symptoms led to ED visit, positive COVID-19 test, and Paxlovid treatment.

Findings:

  • The patient was diagnosed with seronegative IgA vasculitis concurrently with COVID-19.
  • Skin biopsy confirmed intramural IgA deposition via immunofluorescence.
  • Treatment involved tapering prednisone and initiating azathioprine.

Implications:

  • This case underscores the rare association between COVID-19 and IgA vasculitis.
  • It highlights the importance of considering vasculitis in patients with concurrent respiratory and dermatological symptoms during viral infections.
  • Further research may elucidate the pathophysiological link between SARS-CoV-2 and IgA vasculitis.