End Stage Kidney Disease Outcomes in Children and Young Adults with Sickle Cell Disease in the United States Renal

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Rima S Zahr1, Kenneth I Ataga2, Jeffrey D Lebensburger3

  • 1University of Tennessee Health Science Center College of Medicine Memphis.

Research Square
|June 9, 2023
PubMed

Insights

Children and young adults with sickle cell disease (SCD) experience end-stage kidney disease (ESKD) earlier and have worse outcomes. SCD patients face higher mortality and longer transplant wait times compared to matched controls.

Area of Science:

  • Nephrology
  • Pediatric Hematology

Background:

  • Sickle cell disease (SCD) frequently leads to early-onset kidney disease in children and young adults.
  • End-stage kidney disease (ESKD) prevalence and outcomes in pediatric SCD patients are not well-defined.

Approach:

  • Retrospective analysis of the United States Renal Data System (USRDS) from 1998-2019.
  • Examined ESKD outcomes in pediatric and young adult SCD patients.
  • Matched SCD patients with non-SCD ESKD controls.

Key Points:

  • Identified 97 pediatric/young adult SCD patients with ESKD and 96 matched controls.
  • SCD patients had significantly shorter survival (7.0 vs. 12.4 years).
  • SCD patients experienced longer transplant wait times (10.3 vs. 5.6 years).

Conclusions:

  • Pediatric and young adult SCD patients with ESKD exhibit significantly higher mortality rates.
  • SCD patients face prolonged waiting periods for kidney transplantation.
  • These findings highlight the critical impact of SCD on kidney health and transplant outcomes.

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