Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skeletal Muscle Anatomy00:55

Skeletal Muscle Anatomy

89.2K
Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
89.2K
The Muscular System01:18

The Muscular System

4.2K
The muscular system is essential to the body's overall structure and function, playing a crucial role in movement, stability, and internal processes. It consists of three distinct types of muscle tissue: the skeletal, the smooth, and the cardiac muscles.
4.2K
Overview of Skeletal Muscle01:15

Overview of Skeletal Muscle

11.9K
Skeletal muscles are composed of a bundle of muscle fibers and are attached to bones through tendons. Each skeletal muscle fiber is a single muscle cell. The sarcolemma, the plasma membrane of a skeletal muscle cell, consists of a lipid bilayer and glycocalyx that supports muscle fibers. The sarcolemma extends into the muscle cells to form tubular structures called transverse or T-tubules. Each side of the T-tubules consists of a membrane-bound structure called the sarcoplasmic reticulum,...
11.9K
The Bone Matrix01:18

The Bone Matrix

3.3K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
3.3K
Gross Anatomy of Skeletal Muscles01:12

Gross Anatomy of Skeletal Muscles

12.5K
The connective tissues play a significant role in arranging the muscle fibers into a hierarchical structure that forms a complete muscle. Consider a muscle like the bicep brachii, commonly called the bicep. This muscle comprises thousands of muscle fibers enclosed by a protective layer of connective tissue called the endomysium. The endomysium is primarily composed of reticular fibers, a type of thin collagen fiber. It allows the exchange of nutrients and waste products at the fiber level,...
12.5K
Bone Structure01:55

Bone Structure

48.8K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
48.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HyTrax: Deep Sequential Modeling of Serial Musculoskeletal Measurements for Fracture Prediction in the Women's Health Initiative with External Evaluation in the Framingham Heart Study.

medRxiv : the preprint server for health sciences·2026
Same author

Prognostic Association of Handgrip-Defined Probable or Possible Sarcopenia Status and Polygenic Risk with 10-Year Fracture Incidence among Black, Hispanic, and White Women: A Women's Health Initiative Study.

medRxiv : the preprint server for health sciences·2026
Same author

REACT (Real-world Emulated Clinical Trials): A Framework for Drug Repurposing Applied to Osteoporotic Fractures.

medRxiv : the preprint server for health sciences·2026
Same author

Advanced Bayesian BMD-Derived Genome-Wide Polygenic Scores Enhance Clinical FRAX-Based Fracture Risk Prediction in Postmenopausal Women.

Calcified tissue international·2026
Same author

Integrative Harmonization of Phenotypic and Genomic Data Improves Bone Mineral Density Prediction in Multi-Study Osteoporosis Research.

Genetic epidemiology·2026
Same author

Uncovering racial and genetic disparities in FRAX performance for fracture risk assessment in postmenopausal women.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2025

Related Experiment Video

Updated: Jul 27, 2025

Obtaining Quality Extended Field-of-View Ultrasound Images of Skeletal Muscle to Measure Muscle Fascicle Length
09:57

Obtaining Quality Extended Field-of-View Ultrasound Images of Skeletal Muscle to Measure Muscle Fascicle Length

Published on: December 14, 2020

3.8K

Shared Genetic Architecture between Muscle and Bone: Identification and Functional Implications of

Jongyun Jung1, Qing Wu1

  • 1Department of Biomedical Informatics, College of Medicine, The Ohio State University, Ohio, USA.

Biorxiv : the Preprint Server for Biology
|June 9, 2023
PubMed
Summary

This study identifies three novel genes (EPDR1, PKDCC, SPTBN1) with shared genetic links between muscle and bone. These findings offer new insights into the molecular mechanisms connecting musculoskeletal tissues.

Keywords:
EPDR1GWASPKDCCSPTBN1bonebone mineral densityfracturefunctional annotationgenetic architecturemuscle

More Related Videos

Identification of MyoD Interactome Using Tandem Affinity Purification Coupled to Mass Spectrometry
14:47

Identification of MyoD Interactome Using Tandem Affinity Purification Coupled to Mass Spectrometry

Published on: May 17, 2016

9.9K
Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
09:32

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

9.8K

Related Experiment Videos

Last Updated: Jul 27, 2025

Obtaining Quality Extended Field-of-View Ultrasound Images of Skeletal Muscle to Measure Muscle Fascicle Length
09:57

Obtaining Quality Extended Field-of-View Ultrasound Images of Skeletal Muscle to Measure Muscle Fascicle Length

Published on: December 14, 2020

3.8K
Identification of MyoD Interactome Using Tandem Affinity Purification Coupled to Mass Spectrometry
14:47

Identification of MyoD Interactome Using Tandem Affinity Purification Coupled to Mass Spectrometry

Published on: May 17, 2016

9.9K
Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
09:32

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

9.8K

Area of Science:

  • Genetics
  • Molecular Biology
  • Biomedical Science

Background:

  • Emerging evidence suggests a common genetic basis for muscle and bone traits.
  • The molecular pathways underlying this shared genetic architecture are not well understood.

Approach:

  • Utilized advanced statistical functional mapping with genome-wide association study (GWAS) data for bone mineral density and fracture.
  • Focused on genes with high expression in muscle tissue to identify shared genetic architecture between muscle and bone.

Key Points:

  • Identified three genes—EPDR1, PKDCC, and SPTBN1—highly expressed in muscle and potentially involved in bone metabolism.
  • These genes, previously unlinked to bone, show significant expression across various human tissues.
  • The majority of associated single-nucleotide polymorphisms were located in intronic and intergenic regions, suggesting regulatory roles.

Conclusions:

  • This research establishes a framework for uncovering tissue crosstalk through shared genetic architecture, using muscle and bone as a model.
  • Highlights EPDR1, PKDCC, and SPTBN1 as potential key players in the muscle-bone relationship.
  • Recommends further investigation into functional validation, multi-omics, gene-environment interactions, and clinical applications in musculoskeletal disorders.