Related Experiment Video

Updated: Jul 27, 2025

ATAC-Seq Optimization for Cancer Epigenetics Research
07:13

ATAC-Seq Optimization for Cancer Epigenetics Research

Published on: June 30, 2022

4.4K

RNA- and ATAC-sequencing Reveals a Unique

Z K Chatila, A Yadav, J Mares

    Biorxiv : the Preprint Server for Biology
    |June 9, 2023
    PubMed
    Summary

    Neuroinflammation in Parkinson's disease (PD) involves microglial changes. A study found specific microglial subpopulations altered in PD brains, particularly a depleted subpopulation in the substantia nigra, potentially impacting neuronal health.

    More Related Videos

    Mapping Genome-wide Accessible Chromatin in Primary Human T Lymphocytes by ATAC-Seq09:08

    Mapping Genome-wide Accessible Chromatin in Primary Human T Lymphocytes by ATAC-Seq

    Published on: November 13, 2017

    18.1K
    Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq06:24

    Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

    Published on: March 12, 2021

    3.7K

    Related Concept Videos

    RNA-seq03:21

    RNA-seq

    RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
    Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
    10.1K
    Next-generation Sequencing03:00

    Next-generation Sequencing

    The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
    Next-Generation Sequencing Methods
    Although all next-generation methods use different technologies, they all share a set of standard features....
    91.7K
    Sanger Sequencing01:57

    Sanger Sequencing

    DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
    755.2K
    Ribosome Profiling02:24

    Ribosome Profiling

    Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
    Applications of ribosome profiling
    Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
    The technique...
    3.6K
    Maxam-Gilbert Sequencing01:05

    Maxam-Gilbert Sequencing

    In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
    Challenges of the Maxam-Gilbert Method
    The...
    11.3K