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Neurophysiological trajectories in Alzheimer's disease progression.
Kiwamu Kudo1,2, Kamalini G Ranasinghe3, Hirofumi Morise1,2
1Biomagnetic Imaging Laboratory, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, 94143, USA.
Biorxiv : the Preprint Server for Biology
|June 9, 2023
Summary
Neural synchrony changes, specifically decreased alpha and beta bands, appear early in Alzheimer's disease (AD) progression, preceding neurodegeneration and cognitive decline. These alterations in brain oscillations offer insights into AD pathophysiology.
Area of Science:
- Neuroscience
- Biomedical Engineering
Background:
- Alzheimer's disease (AD) involves amyloid-β and tau pathology, leading to synaptic dysfunction, neurodegeneration, and cognitive decline.
- Altered neural oscillations are observed in AD, but their progression and relation to disease severity remain unclear.
Approach:
- Utilized event-based sequencing models (EBMs) to analyze resting-state magnetoencephalography data.
- Investigated trajectories of long-range and local neural synchrony across different stages of AD progression.
Key Points:
- Increased delta-theta band synchrony and decreased alpha and beta band synchrony showed progressive changes across AD stages.
- Decreases in alpha and beta band synchrony were early indicators, preceding neurodegeneration and cognitive decline.
- Long-range synchrony changes were more pronounced than local synchrony changes.
Conclusions:
- Frequency-specific alterations in neuronal synchrony are early indicators of Alzheimer's disease pathophysiology.
- Abnormal neural synchrony evolves progressively throughout the course of AD.
- Connectivity metrics involving multiple brain regions are sensitive to early functional deficits in AD.
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