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High Ambient Temperature in Pregnancy and Risk of Childhood Acute Lymphoblastic Leukemia

Tormod Rogne1,2, Rong Wang1, Pin Wang3

  • 1Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.

Medrxiv : the Preprint Server for Health Sciences
|June 9, 2023
PubMed

Insights

High ambient temperatures during early pregnancy may increase the risk of childhood acute lymphoblastic leukemia (ALL). This finding is particularly relevant for Latino children, highlighting potential environmental factors in pediatric cancer.

Area of Science:

  • Environmental Epidemiology
  • Pediatric Oncology
  • Climate Change and Health

Background:

  • Rising global temperatures pose risks to pregnancy outcomes.
  • Childhood acute lymphoblastic leukemia (ALL) incidence is increasing, with disparities among ethnic groups.
  • Investigating the link between prenatal heat exposure and childhood ALL risk is crucial.

Approach:

  • Utilized California birth and cancer registry data (1982-2015).
  • Matched 6,258 ALL cases with 307,579 controls.
  • Analyzed ambient temperature associations with ALL risk per gestational week using Bayesian meta-regression.

Key Points:

  • A 5°C increase in ambient temperature at gestational week 8 was linked to higher ALL odds.
  • The association was observed for both Latino (OR 1.09) and non-Latino White children (OR 1.05).
  • Sensitivity analyses supported the findings for early pregnancy exposure.

Conclusions:

  • High ambient temperature during early pregnancy is associated with an increased risk of childhood ALL.
  • Further research into mechanistic pathways is needed.
  • Findings may inform strategies to mitigate risks associated with climate change and pediatric cancer.
Abstract

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